{"id":"W2897636829","doi":"10.1016/j.eururo.2018.09.048","title":"Genomic Analysis of Three Metastatic Prostate Cancer Patients with Exceptional Responses to Carboplatin Indicating Different Types of DNA Repair Deficiency","year":2018,"lang":"en","type":"article","venue":"European Urology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Academy of Medical Sciences; Medical Research Council; National Institute for Health and Care Research; Cancer Research UK","keywords":"Carboplatin; Medicine; Prostate cancer; Poly ADP ribose polymerase; DNA repair; Prostate; Cancer; Oncology; Internal medicine; Cancer research; PARP inhibitor; Homologous recombination; Chemotherapy; DNA; Polymerase; Cisplatin; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002469537,0.0001213383,0.0003583742,0.0004538611,0.00005177732,0.000003110933,0.00009818412,0.00001618152,0.0002404239],"category_scores_gemma":[0.0001076723,0.00007815646,0.00007935596,0.0005548364,0.0002777442,0.00001844153,0.00008572447,0.0000822223,0.00001565704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005174278,"about_ca_system_score_gemma":0.0001093339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006087924,"about_ca_topic_score_gemma":0.0001417814,"domain_scores_codex":[0.998703,0.0002139002,0.0003158879,0.0002798596,0.0002591943,0.000228165],"domain_scores_gemma":[0.9991108,0.000106989,0.0001864724,0.0002538596,0.0002520402,0.00008987975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002942843,0.0002369035,0.9851228,0.00003987844,0.0009896349,0.0000124724,0.001294843,0.00006789964,0.007614922,0.00001932514,0.00003582353,0.001622626],"study_design_scores_gemma":[0.001176666,0.003042074,0.9934914,0.00001995746,0.001077184,0.000001141829,0.00002771528,0.0001861057,0.000831158,0.000007111942,0.0000707113,0.00006879157],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981022,0.0002804399,0.00005745993,0.0001820108,0.00003281997,0.0004046668,0.0001177181,0.00002197521,0.000800704],"genre_scores_gemma":[0.999106,0.00002014129,0.0004186025,0.0001031457,0.00002997015,0.00001835614,0.0000621354,0.00002168779,0.0002199772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008368555,"threshold_uncertainty_score":0.3187128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0261167313762709,"score_gpt":0.2990011561839107,"score_spread":0.2728844248076397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}