{"id":"W2897636829","doi":"10.1016/j.eururo.2018.09.048","title":"Genomic Analysis of Three Metastatic Prostate Cancer Patients with Exceptional Responses to Carboplatin Indicating Different Types of DNA Repair Deficiency","year":2018,"lang":"en","type":"article","venue":"European Urology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Academy of Medical Sciences; Medical Research Council; National Institute for Health and Care Research; Cancer Research UK","keywords":"Carboplatin; Medicine; Prostate cancer; Poly ADP ribose polymerase; DNA repair; Prostate; Cancer; Oncology; Internal medicine; Cancer research; PARP inhibitor; Homologous recombination; Chemotherapy; DNA; Polymerase; Cisplatin; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009568324,0.000504402,0.0003758463,0.0006924889,0.0006544515,0.0004574489,0.0002999396,0.000644761,0.0009903691],"category_scores_gemma":[0.001044312,0.00018454,0.000416818,0.0004113849,0.0004091482,0.0001381333,0.0004684995,0.0005185221,0.0001412432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003131602,"about_ca_system_score_gemma":0.0001948839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001707457,"about_ca_topic_score_gemma":0.001433245,"domain_scores_codex":[0.9997857,0.00003251114,0.00002055519,0.00006923357,0.00003921621,0.00005279671],"domain_scores_gemma":[0.999479,0.0001378898,0.000103772,0.00004067456,0.00004907552,0.0001896251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"case_report","study_design_scores_codex":[0.001261158,0.0003827072,0.613448,0.0001464942,0.0001590177,0.2505827,0.002345131,0.0008101502,0.1011548,0.0004837812,0.0007155833,0.02851048],"study_design_scores_gemma":[0.00004633426,0.001682166,0.6650054,0.00001045103,0.0001322708,0.314589,0.0007145008,0.0007251992,0.01450147,0.0003170098,0.00223172,0.00004450639],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979934,0.0001778893,0.0007969533,0.0001230784,0.000009022598,0.00002514582,0.000161041,0.0000265328,0.0006870429],"genre_scores_gemma":[0.9991474,0.00006760729,0.0003191315,0.00006378013,0.00001105967,0.000008845882,0.0001917539,0.000005603422,0.0001848061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001707457,"threshold_uncertainty_score":0.003395021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0261167313762709,"score_gpt":0.2990011561839107,"score_spread":0.2728844248076397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}