{"id":"W2897785134","doi":"10.1016/j.scr.2018.10.016","title":"Generation of human induced pluripotent stem cell (iPSC) line from an unaffected female carrier of mutation in SACSIN gene","year":2018,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministerio de Ciencia e Innovación","keywords":"Induced pluripotent stem cell; Reprogramming; Biology; SOX2; KLF4; Mutation; Immunocytochemistry; Cell culture; Spinocerebellar ataxia; Gene; Molecular biology; Genetics; Cell biology; Cancer research; Embryonic stem cell; Endocrinology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000224107,0.0002536168,0.0003212546,0.0004425643,0.0002947525,0.0002062574,0.0002154835,0.000438036,0.003852702],"category_scores_gemma":[0.0002236732,0.0001442949,0.0002010358,0.0002907263,0.0002381688,0.0001391254,0.0002022073,0.0005064252,0.001054476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001460601,"about_ca_system_score_gemma":0.000225674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005881388,"about_ca_topic_score_gemma":0.0006821121,"domain_scores_codex":[0.9998529,0.000009878473,0.00002612135,0.00004255197,0.00005094645,0.00001765537],"domain_scores_gemma":[0.9998738,0.00002294169,0.0000134544,0.00003251474,0.00002546937,0.00003180233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007381476,0.00006042382,0.0009394586,0.00004683091,0.000007197152,0.002507124,0.0001144463,0.00008492122,0.9914258,0.0006939084,0.0005695855,0.003476425],"study_design_scores_gemma":[0.00006578262,0.0004994091,0.01244165,0.00002831418,0.00006643755,0.01701552,0.000149467,0.001980227,0.9363106,0.00034411,0.03106858,0.00002996523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.958134,0.0009246541,0.02232993,0.000340301,0.0003370538,0.0005130008,0.007394189,0.0005330308,0.009493874],"genre_scores_gemma":[0.9548829,0.001370479,0.01294381,0.0001921997,0.00008029209,0.0003497846,0.008569475,0.0001219489,0.02148928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003852702,"threshold_uncertainty_score":0.01288855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1028725932569353,"score_gpt":0.3693986821260095,"score_spread":0.2665260888690743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}