{"id":"W2897818944","doi":"10.1021/jacs.8b09964","title":"H<sub>4</sub>octox: Versatile Bimodal Octadentate Acyclic Chelating Ligand for Medicinal Inorganic Chemistry","year":2018,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; TRIUMF; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; California HIV/AIDS Research Program","keywords":"Chemistry; Chelation; Ligand (biochemistry); DOTA; Denticity; Metal; Fluorescence; In vivo; Combinatorial chemistry; Carboxylate; In vitro; Metal ions in aqueous solution; Chemical stability; Stereochemistry; Inorganic chemistry; Organic chemistry; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002666377,0.000185326,0.0004409488,0.000008361195,0.0001745822,0.00002004522,0.0003428739,0.00009494303,0.00003888714],"category_scores_gemma":[0.0003465451,0.0001282136,0.0005946638,0.0003951196,0.001000819,0.00006105124,0.00008785237,0.0006686294,0.000005669211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002388828,"about_ca_system_score_gemma":0.0001875952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002408204,"about_ca_topic_score_gemma":5.181887e-8,"domain_scores_codex":[0.9985266,0.00001376549,0.000504668,0.000209672,0.000410502,0.0003347713],"domain_scores_gemma":[0.9983386,0.0002141447,0.000645049,0.000259772,0.000233386,0.0003089875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000190283,0.0001143299,0.00117664,0.00007479808,0.00019065,0.000001633013,0.000238874,8.654795e-7,0.9889559,0.00000187614,0.00652541,0.002528758],"study_design_scores_gemma":[0.001484136,0.0001143935,0.001211908,0.0000970784,0.0003561689,0.0003384864,0.0004271215,0.0004127322,0.9928422,0.0001294523,0.002453684,0.000132623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931806,0.0001058289,0.0003315625,0.005858405,0.00007880672,0.000161333,0.00001118955,0.00002171365,0.0002505436],"genre_scores_gemma":[0.9940188,0.00007824208,0.001514599,0.001982558,0.002307794,0.000009217225,0.000004297938,0.00002719471,0.00005727807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004071726,"threshold_uncertainty_score":0.5228398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01685712605515411,"score_gpt":0.3102651551508409,"score_spread":0.2934080290956868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}