{"id":"W2897874540","doi":"10.1016/j.jaut.2018.09.011","title":"Arginine methylation of FOXP3 is crucial for the suppressive function of regulatory T cells","year":2018,"lang":"en","type":"article","venue":"Journal of Autoimmunity","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; University Health Network","funders":"Structural Genomics Consortium; Japan Society for the Promotion of Science; Innovative Medicines Initiative; Canada Foundation for Innovation; Ontario Genomics Institute","keywords":"FOXP3; Methylation; Arginine; Cell biology; Mutant; Transcription factor; Methyltransferase; Regulatory T cell; Biology; DNA methylation; Chemistry; Gene expression; Gene; Biochemistry; T cell; Immunology; Immune system; Amino acid; IL-2 receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002689996,0.0002233733,0.0002158704,0.0001439375,0.0002890098,0.0003591688,0.0002515535,0.0002888743,0.001772312],"category_scores_gemma":[0.000322379,0.0001458878,0.0002057622,0.00009708884,0.0003938233,0.0002394361,0.0002965709,0.0004760691,0.0004860186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002632719,"about_ca_system_score_gemma":0.0003006404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006512419,"about_ca_topic_score_gemma":0.0008383704,"domain_scores_codex":[0.9998258,0.00002729672,0.00001166976,0.00004314273,0.0000328542,0.00005929191],"domain_scores_gemma":[0.999815,0.00002413374,0.00005867337,0.00002156415,0.00002104803,0.00005958864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003107216,0.00001074872,0.0007188833,0.00001766063,0.000004932952,0.0001069795,0.00001323762,0.00005319298,0.9967031,0.0002369705,0.00006506497,0.001758561],"study_design_scores_gemma":[0.00006911187,0.0002733007,0.03021595,0.000007675056,0.0000313399,0.0008124476,0.0000596391,0.00139545,0.9625314,0.0007349084,0.003854203,0.0000146539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932433,0.001533232,0.002910769,0.0002187492,0.00007313357,0.000009912913,0.0001406202,0.000150382,0.001719937],"genre_scores_gemma":[0.9985861,0.0001585043,0.0004791121,0.00002758087,0.00001214849,0.000002749514,0.00008763845,0.00001864966,0.0006275564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001772312,"threshold_uncertainty_score":0.005928993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01215697257460563,"score_gpt":0.2664178729783916,"score_spread":0.254260900403786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}