{"id":"W2897874540","doi":"10.1016/j.jaut.2018.09.011","title":"Arginine methylation of FOXP3 is crucial for the suppressive function of regulatory T cells","year":2018,"lang":"en","type":"article","venue":"Journal of Autoimmunity","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; University Health Network","funders":"Structural Genomics Consortium; Japan Society for the Promotion of Science; Innovative Medicines Initiative; Canada Foundation for Innovation; Ontario Genomics Institute","keywords":"FOXP3; Methylation; Arginine; Cell biology; Mutant; Transcription factor; Methyltransferase; Regulatory T cell; Biology; DNA methylation; Chemistry; Gene expression; Gene; Biochemistry; T cell; Immunology; Immune system; Amino acid; IL-2 receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005840908,0.0000772317,0.000169972,0.00006146328,0.00008091245,0.000005082197,0.0001560482,0.0001335398,0.00004460346],"category_scores_gemma":[0.0001039235,0.00005875161,0.0001762161,0.00009173394,0.0001669043,0.00001029784,0.00003921523,0.0001006366,4.224149e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002161696,"about_ca_system_score_gemma":0.0001509086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001694218,"about_ca_topic_score_gemma":0.000006601618,"domain_scores_codex":[0.9991682,0.00008154684,0.0004324905,0.00007094797,0.0001640686,0.00008281117],"domain_scores_gemma":[0.9979607,0.00005421153,0.0008894989,0.000262946,0.0008120015,0.00002063354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000814595,0.00004245081,0.00007673573,0.00001913218,0.0001883703,3.897898e-8,0.0002224199,0.000953225,0.985678,0.00003204004,0.002922847,0.009050124],"study_design_scores_gemma":[0.0007893362,0.001098191,0.03181972,0.00003223267,0.0001404143,0.000005085064,0.00009389626,0.0005849056,0.9530543,0.0003399908,0.01198561,0.00005628304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871157,0.001254153,0.01049647,0.0001739945,0.0006935009,0.0001551687,0.00002077944,0.000001591206,0.00008862816],"genre_scores_gemma":[0.9986327,0.0001057686,0.0005167248,0.00003139895,0.0005102336,0.000001890903,0.000009251577,0.00001046613,0.0001815848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03262369,"threshold_uncertainty_score":0.2395821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01215697257460563,"score_gpt":0.2664178729783916,"score_spread":0.254260900403786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}