{"id":"W2897909741","doi":"10.1002/ana.25356","title":"N‐acetylcysteine targets 5 lipoxygenase‐derived, toxic lipids and can synergize with prostaglandin E <sub>2</sub> to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice","year":2018,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":294,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Women and Children’s Health Research Institute","funders":"National Institute on Aging; Burke Foundation; National Institutes of Health; Vanderbilt University; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; Heart and Stroke Foundation of Canada","keywords":"Acetylcysteine; Lipoxygenase; Stroke (engine); Pharmacology; Eicosanoid; Prostaglandin; Chemistry; Prostaglandin E2; Medicine; Enzyme; Arachidonic acid; Internal medicine; Biochemistry; Antioxidant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002119013,0.00057883,0.0004037932,0.0003511128,0.0001365393,0.0002428806,0.0002246598,0.0003169855,0.001179802],"category_scores_gemma":[0.00009447532,0.0001200978,0.000325398,0.0001415618,0.0003143211,0.0002283634,0.0001436816,0.0005129586,0.0002168405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002842891,"about_ca_system_score_gemma":0.0003498396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005620736,"about_ca_topic_score_gemma":0.001631036,"domain_scores_codex":[0.9998763,0.00001744602,0.00001887679,0.0000220292,0.00003473304,0.00003078765],"domain_scores_gemma":[0.9999177,0.000005881388,0.00003011151,0.000007313959,0.00001068921,0.00002817996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001337088,0.0002541727,0.0003594624,0.0002001196,0.00004140562,0.00008212414,0.00001014733,0.0001186706,0.9903599,0.0001598133,0.0002291238,0.006848054],"study_design_scores_gemma":[0.0002140329,0.005153697,0.004090072,0.00002018159,0.00009248417,0.0003019114,0.00001654529,0.000471513,0.9858739,0.00007643151,0.003680675,0.000008437818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814627,0.007604916,0.005365239,0.0004449207,0.0001592062,0.0002354617,0.0009753253,0.0003845253,0.003367747],"genre_scores_gemma":[0.9860212,0.004919068,0.004281744,0.0002150031,0.00004117138,0.0001536895,0.0007716219,0.00002240489,0.003574099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001179802,"threshold_uncertainty_score":0.0039469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01805850180698743,"score_gpt":0.2685483495734654,"score_spread":0.2504898477664779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}