{"id":"W2897914092","doi":"10.1038/s41419-018-1120-x","title":"The Zen of XEN: insight into differentiation, metabolism and genomic integrity","year":2018,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Child and Family Research Institute; Ontario Institute for Regenerative Medicine; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Epiblast; Endoderm; Homeobox protein NANOG; Biology; Embryonic stem cell; Cell biology; Blastocyst; Inner cell mass; Trophoblast; Rex1; Stem cell; Nanog Homeobox Protein; Embryo; SOX2; Induced pluripotent stem cell; Genetics; Embryogenesis; Placenta; Gastrulation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009515342,0.0000828351,0.00007658207,0.00002085278,0.0001512399,0.00003096106,0.0001097328,0.00004532834,0.000009143319],"category_scores_gemma":[0.00007672824,0.00005573891,0.00003203749,0.00002883888,0.000193234,0.000003196017,0.0001813076,0.00004989596,0.00000440078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003507369,"about_ca_system_score_gemma":0.00007276363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002604734,"about_ca_topic_score_gemma":0.00001449231,"domain_scores_codex":[0.99942,0.00005587538,0.0001063857,0.0001986155,0.00008401947,0.0001351347],"domain_scores_gemma":[0.9993986,0.00001434409,0.00003636942,0.0002263716,0.00008247881,0.0002418584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005105625,0.0001122584,0.05519409,0.0001297595,0.00005367719,0.000002964144,0.0002357578,5.078582e-7,0.9368984,0.0006908675,0.001452659,0.00471854],"study_design_scores_gemma":[0.001388795,0.0002011051,0.6115235,0.00001365558,0.0001128611,0.000002140891,0.00008624183,0.0005507467,0.3008495,0.003251646,0.08173805,0.0002817345],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868521,0.01156755,0.0002391379,0.0001389494,0.00005446495,0.000122883,0.00001525565,0.000003079693,0.0010066],"genre_scores_gemma":[0.9969705,0.002067286,0.00006945926,0.00007830298,0.0001175031,0.00000772463,0.00003458486,0.000007502629,0.0006471868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6360489,"threshold_uncertainty_score":0.2272967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009759654714220222,"score_gpt":0.2439251909809408,"score_spread":0.2341655362667206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}