{"id":"W2897914092","doi":"10.1038/s41419-018-1120-x","title":"The Zen of XEN: insight into differentiation, metabolism and genomic integrity","year":2018,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Child and Family Research Institute; Ontario Institute for Regenerative Medicine; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Epiblast; Endoderm; Homeobox protein NANOG; Biology; Embryonic stem cell; Cell biology; Blastocyst; Inner cell mass; Trophoblast; Rex1; Stem cell; Nanog Homeobox Protein; Embryo; SOX2; Induced pluripotent stem cell; Genetics; Embryogenesis; Placenta; Gastrulation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002396195,0.0003133857,0.0003029855,0.0006406295,0.0002082678,0.0007962097,0.0003309207,0.0004466731,0.00133846],"category_scores_gemma":[0.0001354123,0.0002039599,0.0001653815,0.0003284136,0.0007358533,0.0009298863,0.0005335505,0.0008638523,0.0003134398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003944194,"about_ca_system_score_gemma":0.0002341702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003854765,"about_ca_topic_score_gemma":0.0006104963,"domain_scores_codex":[0.9999142,0.00001391999,0.000004073582,0.00002291765,0.00003206296,0.00001285546],"domain_scores_gemma":[0.9999317,0.00001545301,0.00001818719,0.00000961594,0.000008497756,0.00001658409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004046293,0.00002764159,0.002904825,0.0006994749,0.00002957618,0.0005689973,0.0001829718,0.0007714698,0.8559394,0.02928572,0.001030939,0.1081543],"study_design_scores_gemma":[0.000026036,0.0007878813,0.0496956,0.0002643526,0.0001307799,0.005824776,0.0006166338,0.005104344,0.6067986,0.02729188,0.3033828,0.00007636593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3671131,0.5346802,0.05583391,0.003094748,0.0004924556,0.00003960115,0.001081652,0.0003539634,0.03731046],"genre_scores_gemma":[0.7450159,0.2152351,0.01900917,0.0007194061,0.0003053912,0.00003648355,0.0007817686,0.00009303439,0.01880367],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00133846,"threshold_uncertainty_score":0.004477561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009759654714220222,"score_gpt":0.2439251909809408,"score_spread":0.2341655362667206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}