{"id":"W2898075990","doi":"10.1016/j.clcc.2018.09.011","title":"Rationale and Design of the IROCAS Study: Multicenter, International, Randomized Phase 3 Trial Comparing Adjuvant Modified (m) FOLFIRINOX to mFOLFOX6 in Patients With High-Risk Stage III (pT4 and/or N2) Colon Cancer—A UNICANCER GI-PRODIGE Trial","year":2018,"lang":"en","type":"article","venue":"Clinical Colorectal Cancer","topic":"Colorectal Cancer Surgical Treatments","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; McGill University; BC Cancer Agency; Jewish General Hospital; Saskatchewan Cancer Agency","funders":"Direction Générale de l’offre de Soins","keywords":"Medicine; Randomized controlled trial; Internal medicine; Colorectal cancer; Oncology; Adjuvant; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001400914,0.0003906436,0.001820832,0.0001456993,0.0001646005,0.00004544481,0.0002879471,0.0001677891,0.0002273158],"category_scores_gemma":[0.001543979,0.0002344836,0.0001825586,0.0004674782,0.0007651813,0.0001471104,0.0003266036,0.0004437349,0.000001889352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005464616,"about_ca_system_score_gemma":0.0006227695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003038192,"about_ca_topic_score_gemma":0.008880955,"domain_scores_codex":[0.9955292,0.0009258665,0.001492414,0.0008855216,0.0007814216,0.0003856107],"domain_scores_gemma":[0.9962525,0.001854968,0.0007552443,0.0003650928,0.0004702765,0.0003019588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8209761,0.003925748,0.1678259,0.00002199351,0.0006648849,0.00001089387,0.0006032803,0.0001585057,0.00001403286,0.000009592912,0.00006992781,0.00571908],"study_design_scores_gemma":[0.8330415,0.02134904,0.1407323,0.0002494302,0.0006281869,5.449892e-7,0.0000901925,0.003293802,0.0001916305,0.00001227831,0.000173652,0.0002374191],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784018,0.0002121151,0.00008208868,0.0003353497,0.002008327,0.01865874,0.0001822086,0.0000338699,0.00008549554],"genre_scores_gemma":[0.9948668,0.0004333722,0.0002147042,0.0002546742,0.0005127185,0.003427777,0.00001884799,0.00004213207,0.0002289819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02709362,"threshold_uncertainty_score":0.9561963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1020343160540062,"score_gpt":0.4094252559468114,"score_spread":0.3073909398928052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}