{"id":"W2898110679","doi":"10.1093/annonc/mdy424.067","title":"Primary efficacy results from B-F1RST, a prospective phase II trial evaluating blood-based tumour mutational burden (bTMB) as a predictive biomarker for atezolizumab (atezo) in 1L non-small cell lung cancer (NSCLC)","year":2018,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Medicine; Atezolizumab; Internal medicine; Oncology; Lung cancer; Biomarker; Population; Gastroenterology; Cancer; Nivolumab; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002248095,0.001926697,0.002228537,0.0003919227,0.0005450165,0.001484081,0.0008485775,0.001894798,0.005846362],"category_scores_gemma":[0.001806473,0.0005088031,0.002278296,0.0002736995,0.0007857085,0.0009824716,0.0003524793,0.004493785,0.001858943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001019444,"about_ca_system_score_gemma":0.001018424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001179283,"about_ca_topic_score_gemma":0.003208355,"domain_scores_codex":[0.9993656,0.0002635474,0.00002452996,0.0001332682,0.00006958203,0.0001434206],"domain_scores_gemma":[0.9987172,0.0002883857,0.0002579049,0.0001032879,0.00009670135,0.0005365511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8253144,0.01943648,0.01142618,0.001251518,0.003213444,0.0001571488,0.0001869643,0.002930158,0.02146334,0.0004047598,0.01326407,0.1009515],"study_design_scores_gemma":[0.6932789,0.2543204,0.03619407,0.0001251628,0.002815502,0.0003772404,0.00006885767,0.001463751,0.003761483,0.0006384698,0.0068754,0.00008065508],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9642524,0.007659828,0.001139388,0.002567181,0.0004293444,0.002261716,0.01278389,0.0002906693,0.008615557],"genre_scores_gemma":[0.9635562,0.002901866,0.002093652,0.003434014,0.0004759821,0.002309844,0.017064,0.0001072739,0.008057141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005846362,"threshold_uncertainty_score":0.01955801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04701148457266324,"score_gpt":0.3925385242952531,"score_spread":0.3455270397225899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}