{"id":"W2898110679","doi":"10.1093/annonc/mdy424.067","title":"Primary efficacy results from B-F1RST, a prospective phase II trial evaluating blood-based tumour mutational burden (bTMB) as a predictive biomarker for atezolizumab (atezo) in 1L non-small cell lung cancer (NSCLC)","year":2018,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Medicine; Atezolizumab; Internal medicine; Oncology; Lung cancer; Biomarker; Population; Gastroenterology; Cancer; Nivolumab; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006350208,0.0002625465,0.0004650119,0.0001237591,0.00013248,0.00001734885,0.000257919,0.0003224569,0.0000299785],"category_scores_gemma":[0.0009767521,0.0002729902,0.0001940846,0.0001542883,0.0002155482,0.000007797867,0.0001576249,0.0001288522,0.000002268489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001113527,"about_ca_system_score_gemma":0.002827571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001218045,"about_ca_topic_score_gemma":0.0005183736,"domain_scores_codex":[0.9978135,0.0001353872,0.0007105518,0.0007246397,0.0001860107,0.0004299688],"domain_scores_gemma":[0.9977575,0.0005091371,0.0005457507,0.0002902902,0.0007787104,0.0001186438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.3806567,0.004972112,0.0004560675,0.00008214303,0.0006712818,0.0000371267,0.002102581,0.001886594,0.5802417,0.00002795832,0.006768023,0.02209775],"study_design_scores_gemma":[0.3147674,0.09110426,0.006344504,0.0002015783,0.0004681836,0.000006316769,0.0001864416,0.01647507,0.5627308,0.0005830669,0.006470433,0.0006619934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907366,0.0008123786,0.0005699661,0.0007178675,0.0004364653,0.002242934,0.001940058,0.000009701695,0.00253404],"genre_scores_gemma":[0.9938709,0.0001437649,0.002000699,0.0006541805,0.001418101,0.000626601,0.001105552,0.00004085067,0.0001393115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08613215,"threshold_uncertainty_score":0.9999722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04701148457266324,"score_gpt":0.3925385242952531,"score_spread":0.3455270397225899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}