{"id":"W2898119006","doi":"10.1093/annonc/mdy287.078","title":"KEYNOTE-412: Phase III study of pembrolizumab plus chemoradiation vs chemoradiation alone for locally advanced head and neck squamous cell carcinoma (HNSCC)","year":2018,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"EMD Serono; MorphoSys; Swedish Orphan Biovitrum; Astellas Pharma; Genentech; Symphogen; AstraZeneca; Amgen; Pfizer; Eisai; Merck; GlaxoSmithKline","keywords":"Medicine; Pembrolizumab; Head and neck squamous-cell carcinoma; Oncology; Head and neck; Internal medicine; Chemoradiotherapy; Basal cell; Phases of clinical research; Head and neck cancer; Radiation therapy; Chemotherapy; Cancer; Overall survival; Surgery; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002618196,0.002618893,0.002490117,0.000608833,0.0007422719,0.001357152,0.001836932,0.002863934,0.01417755],"category_scores_gemma":[0.001303166,0.0009926358,0.001907796,0.000552401,0.001309222,0.001382175,0.0004871463,0.004984858,0.002480297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001222656,"about_ca_system_score_gemma":0.002903495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001376792,"about_ca_topic_score_gemma":0.003569831,"domain_scores_codex":[0.9994472,0.0002262169,0.00003026359,0.0001179952,0.00005777282,0.0001205193],"domain_scores_gemma":[0.9990267,0.0001518724,0.0002090808,0.00006618721,0.00007038218,0.0004758329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9251746,0.0374681,0.0005511001,0.001145469,0.0008912479,0.00005831513,0.00008230186,0.0006106906,0.01189175,0.0002172174,0.002857683,0.01905153],"study_design_scores_gemma":[0.8671969,0.1290897,0.001101002,0.00003199776,0.0002963544,0.00003494594,0.0000165384,0.0002780858,0.0008881835,0.0001274846,0.000924885,0.00001388482],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9612455,0.005198456,0.001023816,0.001423524,0.0009286314,0.01841183,0.005297499,0.0003520129,0.006118766],"genre_scores_gemma":[0.9571813,0.004049896,0.003080038,0.002801292,0.0005410702,0.01792929,0.003949024,0.00007390036,0.01039419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01417755,"threshold_uncertainty_score":0.04742867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04605862990792877,"score_gpt":0.3704412387882663,"score_spread":0.3243826088803375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}