{"id":"W2898124656","doi":"10.1016/j.biocel.2018.10.011","title":"Experimental diabetes mellitus exacerbates ischemia/reperfusion-induced myocardial injury by promoting mitochondrial fission: Role of down-regulation of myocardial Sirt1 and subsequent Akt/Drp1 interaction","year":2018,"lang":"en","type":"article","venue":"The International Journal of Biochemistry & Cell Biology","topic":"Cardiac Ischemia and Reperfusion","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Lawson Health Research Institute","funders":"","keywords":"Mitochondrial fission; Protein kinase B; Apoptosis; Mitochondrion; Internal medicine; Diabetes mellitus; Medicine; Exacerbation; Endocrinology; Ischemia; Phosphorylation; Reperfusion injury; Chemistry; Pharmacology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004677899,0.0002103212,0.0004757959,0.00009477935,0.00006654147,0.00001812502,0.0002378111,0.0002677408,0.0001409595],"category_scores_gemma":[0.0002124687,0.000144181,0.0003236694,0.0000863442,0.0003269679,0.00008589242,0.0001909848,0.0003136477,0.000001892345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001286948,"about_ca_system_score_gemma":0.0001581447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002939866,"about_ca_topic_score_gemma":1.492755e-7,"domain_scores_codex":[0.9982206,0.0001023668,0.0008046365,0.0002542103,0.000431765,0.0001863763],"domain_scores_gemma":[0.9979801,0.0001687145,0.0008842888,0.0002107355,0.0006383854,0.0001177774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001409316,0.0001941045,0.002175859,0.00003019428,0.0002518226,0.000001914232,0.0005679501,0.000001210082,0.9896237,0.000003284651,0.0007273813,0.005013219],"study_design_scores_gemma":[0.001385433,0.0007191664,0.0001238185,0.0002125837,0.0001307626,0.0001248518,0.0006353291,0.0001541299,0.9952703,0.0000355448,0.001083885,0.000124242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953243,0.001852351,0.00001052527,0.0004862204,0.001348506,0.0001765685,0.00003077216,0.000008920232,0.0007618886],"genre_scores_gemma":[0.9971947,0.000158116,0.0001652452,0.00005864071,0.002275363,0.000005238774,0.00007519735,0.00001657573,0.0000508992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00564651,"threshold_uncertainty_score":0.587953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006243267864317266,"score_gpt":0.2600738014495934,"score_spread":0.2538305335852761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}