{"id":"W2898125316","doi":"10.1172/jci121303","title":"DNA hypermethylation within TERT promoter upregulates TERT expression in cancer","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":187,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; Princess Margaret Cancer Centre; Toronto Western Hospital; Hospital for Sick Children; University of British Columbia; McGill University; University of Calgary; Montreal Neurological Institute and Hospital; University Health Network; SickKids Foundation; University of Toronto","funders":"National Institute of General Medical Sciences; Fundação para a Ciência e a Tecnologia; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Centro de Investigação em Biomedicina","keywords":"DNA methylation; Telomerase; Telomere; Downregulation and upregulation; Cancer; Telomerase reverse transcriptase; Cancer research; CpG site; Methylation; Epigenetics; Biology; Molecular biology; Cancer cell; DNA; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001745157,0.00008703797,0.0001279114,0.0003131268,0.0001114362,0.0001681046,0.00007057052,0.0001362346,0.0008710863],"category_scores_gemma":[0.0003455988,0.00009180889,0.0001090615,0.0002271969,0.0001076259,0.00008749065,0.0001143442,0.0001765393,0.0001460804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001427304,"about_ca_system_score_gemma":0.0001738471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004262694,"about_ca_topic_score_gemma":0.0008700664,"domain_scores_codex":[0.9999119,0.0000201961,0.000007507452,0.00002466741,0.00002199911,0.00001362551],"domain_scores_gemma":[0.9998811,0.0000288993,0.00004152357,0.00001542449,0.00001727635,0.00001576186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003033896,0.00003141787,0.03293407,0.00008320402,0.00003021615,0.000294048,0.0001078089,0.0002040744,0.9495977,0.0001103292,0.000100941,0.01620285],"study_design_scores_gemma":[0.00002561719,0.0006672861,0.3655034,0.0000255478,0.0001084589,0.003446825,0.0001559688,0.001560592,0.6225634,0.0003474582,0.0055834,0.00001205277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944285,0.003119885,0.00127201,0.00005138271,0.000008812259,0.00001697762,0.0001438486,0.00003749941,0.0009211315],"genre_scores_gemma":[0.9977685,0.000965083,0.0005566631,0.0000239162,0.0000057616,0.000007791,0.000144551,0.000003023396,0.0005247918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008710863,"threshold_uncertainty_score":0.002914071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1029639817825064,"score_gpt":0.4108224385512192,"score_spread":0.3078584567687129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}