{"id":"W2898125316","doi":"10.1172/jci121303","title":"DNA hypermethylation within TERT promoter upregulates TERT expression in cancer","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":187,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; Princess Margaret Cancer Centre; Toronto Western Hospital; Hospital for Sick Children; University of British Columbia; McGill University; University of Calgary; Montreal Neurological Institute and Hospital; University Health Network; SickKids Foundation; University of Toronto","funders":"National Institute of General Medical Sciences; Fundação para a Ciência e a Tecnologia; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Centro de Investigação em Biomedicina","keywords":"DNA methylation; Telomerase; Telomere; Downregulation and upregulation; Cancer; Telomerase reverse transcriptase; Cancer research; CpG site; Methylation; Epigenetics; Biology; Molecular biology; Cancer cell; DNA; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001717291,0.0001395353,0.0005005326,0.0002012834,0.00004935205,0.00002579059,0.0001138712,0.0002304584,0.0001174536],"category_scores_gemma":[0.001654778,0.00009855381,0.0001371915,0.0002637277,0.0003246775,0.0004137082,0.00002462127,0.0004846745,0.00001555988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006515008,"about_ca_system_score_gemma":0.0003366374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002928391,"about_ca_topic_score_gemma":0.00003505855,"domain_scores_codex":[0.9972311,0.0002435508,0.001690796,0.000214254,0.0004476521,0.0001726141],"domain_scores_gemma":[0.9979483,0.0002255616,0.0009212205,0.0001932952,0.0004345824,0.0002770589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000616841,0.0002186505,0.6966261,0.00006612568,0.00003287184,0.00003702457,0.001341169,0.0000169891,0.2758858,0.00001745942,0.001154672,0.02398632],"study_design_scores_gemma":[0.001855208,0.0008549285,0.7813328,0.001438302,0.00005825742,0.00006399598,0.00006750869,0.001621748,0.2101352,0.001693202,0.0007603677,0.0001184984],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948869,0.0001576298,0.0001680881,0.003457086,0.0009818485,0.0002026721,0.000001200315,0.00001717038,0.0001273491],"genre_scores_gemma":[0.9895488,0.0000872578,0.00707577,0.001167909,0.001832976,0.000004170647,0.000005370776,0.00001820196,0.0002595154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08470669,"threshold_uncertainty_score":0.4018908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1029639817825064,"score_gpt":0.4108224385512192,"score_spread":0.3078584567687129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}