{"id":"W2898156509","doi":"10.1016/j.seizure.2018.10.012","title":"Progesterone, 5a-dihydropogesterone and allopregnanolone's effects on seizures: A review of animal and clinical studies","year":2018,"lang":"en","type":"review","venue":"Seizure","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Ontario Brain Institute","keywords":"Allopregnanolone; Neuroactive steroid; Pharmacology; Seizure threshold; Epilepsy; Metabolite; GABAA receptor; Medicine; Progesterone receptor; Status epilepticus; Receptor; Endocrinology; Internal medicine; Anticonvulsant; Estrogen receptor; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001066852,0.0007016027,0.002876846,0.0002752889,0.0002441094,0.00005070042,0.0007215362,0.0003606948,0.00001211725],"category_scores_gemma":[0.003119876,0.0004865487,0.0003148924,0.0006756014,0.002313004,0.0001779532,0.000925804,0.001143604,0.00007430125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003232747,"about_ca_system_score_gemma":0.0002442602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":6.484289e-7,"about_ca_topic_score_gemma":6.057269e-7,"domain_scores_codex":[0.9933572,0.002420299,0.0011058,0.001794163,0.0006566566,0.0006658841],"domain_scores_gemma":[0.9948381,0.003404911,0.0006625163,0.0007027898,0.0001010867,0.0002906047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001792521,0.0004397137,0.00004169302,0.4509419,0.0001965006,0.002148573,0.00008795727,5.39218e-9,0.002440098,0.00007943482,0.009835848,0.5336091],"study_design_scores_gemma":[0.0007054909,0.007597288,0.00002165827,0.2050201,0.001025354,0.001335977,0.000004960342,0.000002014849,0.003157057,0.00002151654,0.7805046,0.0006040135],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.009232296,0.9868521,1.273898e-7,0.0004056338,0.0005636735,0.00276093,0.00004200678,0.00006957404,0.00007364449],"genre_scores_gemma":[0.000298994,0.9962108,0.00001282234,0.002533836,0.0002665294,0.0001760806,0.000001685635,0.00007845651,0.0004208454],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7706687,"threshold_uncertainty_score":0.9997586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2249771689909522,"score_gpt":0.5157252265124023,"score_spread":0.2907480575214501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}