{"id":"W2898159486","doi":"10.1093/nar/gky1011","title":"Human MARF1 is an endoribonuclease that interacts with the DCP1:2 decapping complex and degrades target mRNAs","year":2018,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Jewish General Hospital","funders":"European Research Council; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Endoribonuclease; Cell biology; RNA-binding protein; Messenger RNA; Genetics; RNA interference; RNA; Somatic cell; Psychological repression; Gene; Molecular biology; Gene expression; RNase P","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001000053,0.0004226773,0.0002922631,0.0001827478,0.0002868226,0.0003143196,0.0001861036,0.0004056064,0.001901132],"category_scores_gemma":[0.0001555936,0.00019466,0.0002930047,0.0001458168,0.0001221516,0.0002009164,0.0001555648,0.0003004086,0.001337735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005697732,"about_ca_system_score_gemma":0.0002334308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009042085,"about_ca_topic_score_gemma":0.001261698,"domain_scores_codex":[0.9999319,0.000005799611,0.000003114678,0.00002672624,0.00002209587,0.00001044289],"domain_scores_gemma":[0.9999524,0.000007016041,0.00001507403,0.000003482486,0.000006853711,0.00001521311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002049478,0.00004230588,0.003713912,0.0001756077,0.00003797414,0.0005116566,0.00005559051,0.0008352381,0.9758637,0.0006767284,0.001117752,0.01676469],"study_design_scores_gemma":[0.00007593645,0.0002579803,0.02311378,0.0000266592,0.0000474623,0.005206806,0.00009367256,0.01169324,0.8895619,0.000477398,0.06940877,0.0000363811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9689592,0.007090827,0.01758329,0.0004452731,0.00007834411,0.00004608398,0.001158859,0.0004977184,0.004140569],"genre_scores_gemma":[0.9609892,0.002501322,0.02078521,0.0001470383,0.00002740117,0.00003378482,0.004697317,0.00004746998,0.01077137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001901132,"threshold_uncertainty_score":0.006359875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08403367660578026,"score_gpt":0.3712630863503537,"score_spread":0.2872294097445734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}