{"id":"W2898196508","doi":"10.3390/genes9110522","title":"Valproic Acid Inhibits Proliferation and Reduces Invasiveness in Glioma Stem Cells Through Wnt/β Catenin Signalling Activation","year":2018,"lang":"en","type":"article","venue":"Genes","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Università degli Studi di Milano-Bicocca; Ministero dell’Istruzione, dell’Università e della Ricerca; Fondazione Cariplo; Wellcome Trust","keywords":"Wnt signaling pathway; Catenin; Valproic Acid; Glioma; Stem cell; Cancer research; Beta-catenin; Hedgehog signaling pathway; Cell biology; Chemistry; Biology; Signal transduction; Neuroscience; Epilepsy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009156173,0.0003640207,0.0004652319,0.0004687566,0.0001447054,0.0003071741,0.0001654577,0.0001983744,0.001487777],"category_scores_gemma":[0.00009934087,0.0001192055,0.0004809783,0.0003228955,0.0001406439,0.0001406426,0.0001565668,0.0005544252,0.0002525416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002387048,"about_ca_system_score_gemma":0.0003343965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001350121,"about_ca_topic_score_gemma":0.003102912,"domain_scores_codex":[0.999889,0.00001348845,0.00001514613,0.00001881159,0.00003854312,0.00002506685],"domain_scores_gemma":[0.999964,0.000004989164,0.00001028138,0.000003063293,0.000007016604,0.00001069892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001274409,0.0002079403,0.001214431,0.0004629653,0.00007211261,0.0001649812,0.000055548,0.0003545397,0.9797174,0.0001186503,0.0005453595,0.01581177],"study_design_scores_gemma":[0.0001816565,0.002297021,0.02108014,0.0000459826,0.0001747094,0.0004233262,0.00008779937,0.001362693,0.9622428,0.0001650417,0.01192174,0.00001707329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825146,0.01238647,0.0008902698,0.0002198501,0.00006833696,0.00004424816,0.001710176,0.0001925243,0.001973649],"genre_scores_gemma":[0.9848194,0.007585736,0.001640721,0.0001741838,0.0000172967,0.00008800476,0.0030604,0.00003140346,0.002582926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001487777,"threshold_uncertainty_score":0.004977047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02528529167671391,"score_gpt":0.2791653156324453,"score_spread":0.2538800239557314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}