{"id":"W2898217468","doi":"10.1093/annonc/mdy281.111","title":"Dose finding and safety study of reovirus (Reo) with irinotecan/ fluorouracil/ leucovorin/ bevacizumab (FOLFIRI/B) in patients with KRAS mutant metastatic colorectal cancer (mCRC): Final results","year":2018,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"","keywords":"FOLFIRI; Medicine; Irinotecan; Neutropenia; KRAS; Bevacizumab; Internal medicine; Oxaliplatin; Colorectal cancer; Gastroenterology; Febrile neutropenia; Oncology; Cancer; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009349862,0.0007303552,0.0009922769,0.0002477393,0.0003032592,0.0006468432,0.0005229735,0.0006650568,0.002055237],"category_scores_gemma":[0.0007480365,0.000323853,0.000787717,0.0003150158,0.0005517122,0.0005252447,0.0002346143,0.001536024,0.0003852643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008721254,"about_ca_system_score_gemma":0.0007491384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007211198,"about_ca_topic_score_gemma":0.001266066,"domain_scores_codex":[0.9995998,0.0001870359,0.00002143507,0.0000794493,0.00003784255,0.00007437736],"domain_scores_gemma":[0.9994809,0.0001018245,0.0001142429,0.00006335007,0.00003852768,0.0002011465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5664827,0.08747246,0.01771389,0.0006590445,0.00119758,0.0004893756,0.0006991434,0.004682553,0.1515435,0.0003899615,0.001675675,0.1669941],"study_design_scores_gemma":[0.0633618,0.8995004,0.01730359,0.00002862631,0.000444954,0.0005220134,0.00007732599,0.001073484,0.01510953,0.0001072157,0.002449399,0.0000216278],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972951,0.0007376605,0.0004230209,0.00008015599,0.00002085832,0.0005068203,0.0001842311,0.00002838682,0.0007237807],"genre_scores_gemma":[0.9978952,0.0002590049,0.0006030418,0.00007808694,0.00002977018,0.0002461128,0.0002582253,0.000009508256,0.0006209881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002055237,"threshold_uncertainty_score":0.006875396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05812947739810616,"score_gpt":0.3745575300499034,"score_spread":0.3164280526517972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}