{"id":"W2898219654","doi":"10.1016/j.mad.2018.10.004","title":"Methionine restriction leads to hyperhomocysteinemia and alters hepatic H2S production capacity in Fischer-344 rats","year":2018,"lang":"en","type":"article","venue":"Mechanisms of Ageing and Development","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Canada Research Chairs","keywords":"Cystathionine beta synthase; Methionine; Hyperhomocysteinemia; Transsulfuration; Homocysteine; Internal medicine; Cysteine; Cystathionine gamma-lyase; Endocrinology; Methionine Adenosyltransferase; Biology; Transmethylation; Enzyme; Metabolism; Biochemistry; Amino acid; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006479801,0.0001125357,0.0002219971,0.0002900188,0.00009965479,0.0000141006,0.00003403734,0.00007235678,0.00001202541],"category_scores_gemma":[0.000185196,0.0000950684,0.0000120891,0.0002745455,0.00004572951,0.00006967271,0.0000596951,0.0001330299,0.000007672174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008045238,"about_ca_system_score_gemma":0.00007482769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002654369,"about_ca_topic_score_gemma":0.0001983364,"domain_scores_codex":[0.9989495,0.00004578559,0.0002566692,0.000284734,0.0002605147,0.0002027679],"domain_scores_gemma":[0.9995751,0.0000234725,0.00004312764,0.000127659,0.000116793,0.0001138351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002831504,0.0001121223,0.00768721,0.0003501181,0.00004220406,0.00004350733,0.003075489,0.000006498317,0.9605369,0.0001675981,0.0001978517,0.02749738],"study_design_scores_gemma":[0.0007623063,0.0009367509,0.1046341,0.0004098033,0.00001951518,0.00003709318,0.0003626303,0.000226538,0.8916548,0.0002661934,0.0005310773,0.0001591508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952477,0.00005647519,0.003257187,0.0007826705,0.0001271355,0.0003432168,5.823196e-7,0.00002257845,0.0001624715],"genre_scores_gemma":[0.9669912,0.00005417306,0.03239707,0.000101559,0.00004971443,0.00002159678,0.000005155109,0.00001046977,0.0003690274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09694694,"threshold_uncertainty_score":0.3876777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04895677434489432,"score_gpt":0.2868476449975434,"score_spread":0.2378908706526491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}