{"id":"W2898234690","doi":"10.1016/j.jtho.2018.12.006","title":"EGFR and ERBB2 Germline Mutations in Chinese Lung Cancer Patients and Their Roles in Genetic Susceptibility to Cancer","year":2019,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"Public Health Ontario","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Germline; Lung cancer; Germline mutation; Medicine; T790M; Epidermal growth factor receptor; Cancer research; Cancer; Mutation; Oncology; Genetics; Internal medicine; Biology; Gene; Gefitinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002514808,0.0002965587,0.0003114972,0.001509184,0.0009069255,0.0005057841,0.0003249119,0.0003838043,0.002594193],"category_scores_gemma":[0.0009728947,0.0002913215,0.0004547258,0.00172131,0.0004463479,0.0003375211,0.0002768245,0.0003913058,0.0001775771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005735398,"about_ca_system_score_gemma":0.0007226797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01991442,"about_ca_topic_score_gemma":0.01615396,"domain_scores_codex":[0.9997124,0.00004217092,0.00004157837,0.00006441996,0.00005468179,0.00008465744],"domain_scores_gemma":[0.9996263,0.0001065156,0.00009998596,0.00002276377,0.00004642247,0.00009792385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001613699,0.00005014177,0.9923548,0.00001958853,0.00006785196,0.002156701,0.000596181,0.00008149382,0.001959547,0.0001355525,0.00009944738,0.00231725],"study_design_scores_gemma":[0.00001000662,0.00005739853,0.9955322,0.000005965239,0.0001084382,0.002438627,0.0007420933,0.0002915905,0.0003237709,0.0001635383,0.0003165092,0.000009864493],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989678,0.0002414259,0.00003618538,0.00006542273,0.00000484495,0.000003435273,0.00006551858,0.000001764967,0.0006137036],"genre_scores_gemma":[0.9995449,0.00009524179,0.0000265267,0.00002464902,0.000006164194,0.000002025796,0.00004801922,0.000001132872,0.000251217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01991442,"threshold_uncertainty_score":0.03959703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008632132505897637,"score_gpt":0.4281880912676962,"score_spread":0.4195559587617986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}