{"id":"W2898243427","doi":"10.1101/454249","title":"Heritability and genetic variance of dementia with Lewy bodies","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Institute on Aging; NIHR Oxford Biomedical Research Centre; National Health and Medical Research Council; Medical Research Council; National Institutes of Health; Hjartavernd; Institute of Genetics; Agence Nationale de la Recherche; Assistance publique-Hôpitaux de Paris; Hersenstichting; Parkinson's Disease Foundation; McGill University; University of Dundee; Samfundet Folkhälsan; Bundesministerium für Bildung und Forschung; Landspítali Háskólasjúkrahús; Krembil Foundation; University of Toronto; Generalitat de Catalunya; Institut National de la Santé et de la Recherche Médicale; Parkinson's UK; Folkhälsanin Tutkimussäätiö; National Institute for Health and Care Research; Alzheimer Society; Alzheimer's Society; Université de Lille; University of California, San Diego; Johns Hopkins University; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; University College London Hospitals NHS Foundation Trust; EU Joint Programme – Neurodegenerative Disease Research; Erasmus Medisch Centrum; Neuroscience Research Australia; University College London; Wellcome Trust; Memorial University of Newfoundland; University of New South Wales; Consortium canadien en neurodégénérescence associée au vieillissement; University of Pennsylvania; U.S. Department of Veterans Affairs; U.S. Department of Defense; Helene Morgan Babcock and Alfred Babcock Memorial Scholarship Trust; Centre hospitalier régional universitaire de Lille; Helsingin Yliopisto; Centres de Recerca de Catalunya; Helsingin ja Uudenmaan Sairaanhoitopiiri; Little Family Foundation; American Parkinson Disease Association; Alzheimer's Association; Parkinson Vereniging; Michael J. Fox Foundation for Parkinson's Research; National Heart, Lung, and Blood Institute; Itä-Suomen Yliopisto; Mayo Clinic; U.S. Department of Health and Human Services","keywords":"Heritability; Dementia with Lewy bodies; Genome-wide association study; Biology; Linkage disequilibrium; Genetic correlation; Single-nucleotide polymorphism; Genetic variation; Genetic association; Genetics; Disease; SNP; Genetic architecture; Dementia; Allele; Phenotype; Evolutionary biology; Genotype; Medicine; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001055877,0.0002555877,0.0003618158,0.0008481899,0.0002133391,0.0004259346,0.0001684429,0.0002179368,0.001413692],"category_scores_gemma":[0.002880777,0.0001545967,0.0002802013,0.000726814,0.0004281753,0.0001701634,0.0004643589,0.0003654092,0.0001265061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001885166,"about_ca_system_score_gemma":0.0001025173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003860401,"about_ca_topic_score_gemma":0.002326349,"domain_scores_codex":[0.9992226,0.0002979485,0.00004703905,0.0002387287,0.0001388162,0.00005489917],"domain_scores_gemma":[0.998583,0.0007401736,0.0003548727,0.0001942031,0.00006376793,0.00006406784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003130437,0.00007092008,0.9651012,0.00005765278,0.001408495,0.0008324965,0.0003965773,0.002497698,0.01216093,0.002269054,0.0007409393,0.01415091],"study_design_scores_gemma":[0.00001603166,0.0000302013,0.9947323,0.00001436179,0.0001210364,0.0004059291,0.00007960536,0.002267074,0.000548856,0.001455951,0.0003201207,0.000008659654],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935809,0.0006990643,0.004190544,0.0001410486,0.0000150813,0.00001045309,0.0005144642,0.00005223598,0.0007962648],"genre_scores_gemma":[0.9992743,0.00009808702,0.0003097268,0.000009604863,0.000009936802,0.000003323213,0.0001962209,0.000005108864,0.00009372578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003860401,"threshold_uncertainty_score":0.007675886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009895889363672224,"score_gpt":0.2182178726534698,"score_spread":0.2083219832897976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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