{"id":"W2898272327","doi":"10.1093/annonc/mdy285.144","title":"Preliminary safety, efficacy, and PK/PD characterization from GARNET, a phase I clinical trial of the anti–PD-1 monoclonal antibody, TSR-042, in patients with recurrent or advanced MSI-H endometrial cancer","year":2018,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; University of British Columbia; BC Cancer Agency","funders":"","keywords":"Medicine; Internal medicine; Adverse effect; Endometrial cancer; Cohort; Response Evaluation Criteria in Solid Tumors; Gastroenterology; Progressive disease; Oncology; Biomarker; Pharmacokinetics; Peripheral blood mononuclear cell; Clinical trial; Phases of clinical research; Cancer; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003060538,0.0001510437,0.0004519853,0.00006183836,0.0000398793,0.000006151126,0.0001907385,0.0002116612,0.00003189444],"category_scores_gemma":[0.0006418749,0.0001073232,0.00008009246,0.0001579273,0.0003421074,0.000007363257,0.0001951477,0.000111603,4.889764e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001523622,"about_ca_system_score_gemma":0.0004308233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007945109,"about_ca_topic_score_gemma":0.0002206419,"domain_scores_codex":[0.9984613,0.0001867935,0.0006538757,0.0003606849,0.0001354184,0.0002019045],"domain_scores_gemma":[0.9985838,0.0002534867,0.000556603,0.0002812233,0.0002546248,0.00007024024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5693665,0.004647524,0.06143879,0.00002572817,0.0002372205,0.00000360006,0.0001587567,0.00002218787,0.05213333,0.0000172709,0.0006880481,0.3112611],"study_design_scores_gemma":[0.157293,0.07283528,0.6960122,0.000126894,0.0001026728,0.000001285507,0.00001681463,0.00007037524,0.02856193,0.0000262299,0.04469293,0.0002603942],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967785,0.0003402345,0.00006566943,0.0003161726,0.0009828305,0.0007830369,0.0006655272,0.000002260035,0.00006571833],"genre_scores_gemma":[0.9945886,0.003805882,0.0001832728,0.0002768706,0.0006623538,0.00002308036,0.0004274083,0.00001579963,0.0000167264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6345735,"threshold_uncertainty_score":0.4376512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05334834220999658,"score_gpt":0.4158929776229871,"score_spread":0.3625446354129905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}