{"id":"W2898281580","doi":"10.1093/annonc/mdy424.035","title":"ERA 223: A phase III trial of radium-223 (Ra-223) in combination with abiraterone acetate and prednisone/prednisolone for the treatment of asymptomatic or mildly symptomatic chemotherapy-naïve patients (pts) with bone-predominant metastatic castration-resistant prostate cancer (mCRPC)","year":2018,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Medicine; Abiraterone acetate; Clinical endpoint; Internal medicine; Asymptomatic; Denosumab; Prednisone; Gastroenterology; Phases of clinical research; Placebo; Urology; Randomized controlled trial; Clinical trial; Surgery; Cancer; Prostate cancer; Osteoporosis; Androgen deprivation therapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009542475,0.001295436,0.001880899,0.0004338397,0.0003323377,0.001212021,0.0009151489,0.001119096,0.004422025],"category_scores_gemma":[0.0007212961,0.0005934004,0.001605068,0.0004529365,0.0008572837,0.0006715111,0.0004084759,0.00291992,0.001522712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004882442,"about_ca_system_score_gemma":0.001314617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001086653,"about_ca_topic_score_gemma":0.003568601,"domain_scores_codex":[0.9997219,0.0001273683,0.00001599248,0.00003844007,0.00002818452,0.0000681326],"domain_scores_gemma":[0.9996523,0.00005683751,0.00007868652,0.00003150102,0.0000165905,0.0001641774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.689217,0.02693195,0.005024686,0.002292405,0.004041802,0.000522456,0.0003101847,0.004519056,0.03351161,0.0008060371,0.01105565,0.2217671],"study_design_scores_gemma":[0.7340917,0.2358474,0.01228642,0.0001266593,0.002428315,0.0009508149,0.00009262131,0.001823297,0.003753439,0.0005043952,0.008030129,0.00006476989],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784241,0.009439912,0.0007771957,0.001111748,0.0004269131,0.00158535,0.001583536,0.0006345604,0.006016756],"genre_scores_gemma":[0.9746425,0.008425404,0.002725441,0.002097046,0.0004319831,0.001472992,0.003093748,0.0001129647,0.006997961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004422025,"threshold_uncertainty_score":0.01479322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05907478505180859,"score_gpt":0.3967821089473589,"score_spread":0.3377073238955504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}