{"id":"W2898284644","doi":"10.22203/ecm.v036a15","title":"Thermoreversible hyaluronan-hydrogel and autologous nucleus pulposus cell delivery regenerates human intervertebral discs in an ex vivo, physiological organ culture model","year":2018,"lang":"en","type":"article","venue":"European Cells and Materials","topic":"Spine and Intervertebral Disc Pathology","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Shriners Hospitals for Children - Canada; Montreal General Hospital; Douglas Mental Health University Institute; McGill University","funders":"Canadian Institutes of Health Research; AOSpine; Réseau de Recherche en Santé Buccodentaire et Osseuse","keywords":"Self-healing hydrogels; Hyaluronic acid; Intervertebral disc; Tissue engineering; Ex vivo; Biomedical engineering; Regeneration (biology); Proteoglycan; Viability assay; Lumbar; Matrix (chemical analysis); Organ culture; Cell culture; Cell; Extracellular matrix; Chemistry; Cell biology; In vitro; Anatomy; Medicine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002973118,0.0003701792,0.0002564105,0.0002233538,0.0001015445,0.0002154355,0.0001967141,0.0003085351,0.0006644365],"category_scores_gemma":[0.0001145529,0.0001531524,0.0002294056,0.0001278434,0.0002302603,0.0002112294,0.0001765769,0.0002991594,0.0002134101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001761707,"about_ca_system_score_gemma":0.0002525022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005134639,"about_ca_topic_score_gemma":0.0009661847,"domain_scores_codex":[0.9998235,0.00002530429,0.00002035402,0.00004384164,0.00006264101,0.00002435247],"domain_scores_gemma":[0.9999198,0.00001561389,0.00002948504,0.00001205305,0.000009883903,0.00001321102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006458976,0.00003161955,0.00003841508,0.00005290393,0.0000020953,0.00004546724,0.00001915381,0.00009106332,0.9985844,0.00003186241,0.000009787269,0.001028511],"study_design_scores_gemma":[0.00001404656,0.0008217201,0.001198499,0.000008557944,0.0000144097,0.0002483398,0.00002301972,0.0007473691,0.9957187,0.00001920457,0.001182211,0.000004065393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876627,0.002819502,0.008104059,0.00004010061,0.00003981003,0.00007712402,0.0001396749,0.0000646942,0.00105245],"genre_scores_gemma":[0.9886822,0.001382161,0.00669043,0.00003134541,0.00001482869,0.0001084881,0.0001888914,0.00001435467,0.002887289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006644365,"threshold_uncertainty_score":0.002222776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02741228088599831,"score_gpt":0.2671402191723862,"score_spread":0.2397279382863879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}