{"id":"W2898284644","doi":"10.22203/ecm.v036a15","title":"Thermoreversible hyaluronan-hydrogel and autologous nucleus pulposus cell delivery regenerates human intervertebral discs in an ex vivo, physiological organ culture model","year":2018,"lang":"en","type":"article","venue":"European Cells and Materials","topic":"Spine and Intervertebral Disc Pathology","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Shriners Hospitals for Children - Canada; Montreal General Hospital; Douglas Mental Health University Institute; McGill University","funders":"Canadian Institutes of Health Research; AOSpine; Réseau de Recherche en Santé Buccodentaire et Osseuse","keywords":"Self-healing hydrogels; Hyaluronic acid; Intervertebral disc; Tissue engineering; Ex vivo; Biomedical engineering; Regeneration (biology); Proteoglycan; Viability assay; Lumbar; Matrix (chemical analysis); Organ culture; Cell culture; Cell; Extracellular matrix; Chemistry; Cell biology; In vitro; Anatomy; Medicine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002106631,0.0002801857,0.0004678564,0.00007116742,0.0001139381,0.00007205056,0.0001548807,0.0001152299,0.0004736282],"category_scores_gemma":[0.00001009701,0.0001962928,0.00005091647,0.00006074774,0.0002898578,0.0001629006,0.0002626806,0.000125046,0.00008961677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001831799,"about_ca_system_score_gemma":0.00001685695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000498567,"about_ca_topic_score_gemma":0.00002362504,"domain_scores_codex":[0.998461,0.0002188856,0.0003660523,0.0005286665,0.00008070045,0.0003447116],"domain_scores_gemma":[0.9994141,0.000002503162,0.0001007466,0.0002704272,0.00005390902,0.0001583356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007052516,0.0002056161,0.000127214,0.00007603225,0.0000130714,0.0001889531,0.0008530435,0.000002040453,0.9950461,0.0002133944,0.002858489,0.0003454754],"study_design_scores_gemma":[0.002097778,0.004762467,0.02402275,0.0001274304,0.00007833185,0.0001104946,0.0003258145,0.001015715,0.9664408,0.0003845632,0.000237235,0.0003966243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952507,0.0002006458,0.00002663535,0.0000518509,0.0001674274,0.0002263526,0.00006509785,0.00007199193,0.00393927],"genre_scores_gemma":[0.9949437,0.0001178727,0.001450168,0.0008129698,0.0002684318,0.00000332945,0.00007424842,0.00004912192,0.002280209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02860535,"threshold_uncertainty_score":0.8004588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02741228088599831,"score_gpt":0.2671402191723862,"score_spread":0.2397279382863879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}