{"id":"W2898290288","doi":"10.1126/sciimmunol.aar7754","title":"Type 3 cytokines IL-17A and IL-22 drive TGF-β–dependent liver fibrosis","year":2018,"lang":"en","type":"article","venue":"Science Immunology","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":155,"is_retracted":false,"has_abstract":true,"ca_institutions":"Caprion (Canada); Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canadian Liver Foundation","keywords":"Transforming growth factor; Fibrosis; Liver fibrosis; Interleukin; Immunology; Interleukin 17; Interleukin 23; Cytokine; Interleukin 6; Biology; Medicine; Pathology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003368612,0.0001330451,0.0001419643,0.00009867079,0.0003501819,0.00003376516,0.0003187107,0.0001982902,0.00005486893],"category_scores_gemma":[0.0001317935,0.0001072364,0.00002705655,0.000265948,0.001882101,0.00001230573,0.0002947683,0.0001022411,0.000161255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002630401,"about_ca_system_score_gemma":0.0002857213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001186622,"about_ca_topic_score_gemma":0.00003765432,"domain_scores_codex":[0.9987267,0.00005993108,0.0001687904,0.0004915314,0.0001327386,0.0004202931],"domain_scores_gemma":[0.9991866,0.00001199691,0.00008328573,0.0003327817,0.0002985487,0.00008674899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006744634,0.00002642349,0.002706905,0.000008008403,0.00002409778,0.000003824202,0.0001833398,9.449288e-7,0.9922922,0.0007570137,0.000456828,0.003472982],"study_design_scores_gemma":[0.0008775324,0.003867344,0.1176626,0.0000592997,0.00002859947,0.0003205775,0.0006009176,0.00006344936,0.7832983,0.0003339448,0.09240543,0.0004820217],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910086,0.001884367,0.00008962845,0.0002365018,0.001038019,0.0001532919,0.00001095661,0.00001844646,0.005560138],"genre_scores_gemma":[0.9966486,0.0009738597,0.000287302,0.0001924798,0.0001839678,0.000005917776,0.00000863933,0.00001011414,0.001689186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2089939,"threshold_uncertainty_score":0.6934679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009213056752613831,"score_gpt":0.2628143457525201,"score_spread":0.2536012889999062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}