{"id":"W2898292223","doi":"10.1016/j.chembiol.2018.10.002","title":"Small-Molecule Allosteric Triggers of Clostridium difficile Toxin B Auto-proteolysis as a Therapeutic Strategy","year":2018,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; National Research Council Canada; McMaster University; McGill University Health Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Crohn's and Colitis Canada; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Allosteric regulation; Proteolysis; Clostridium difficile toxin B; Clostridium difficile toxin A; Clostridium difficile; Toxin; Protease; Microbiology; Biochemistry; Biology; Intracellular; Chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001641646,0.0002307878,0.0001700591,0.0001189696,0.0001400101,0.0002036107,0.0001967763,0.000298256,0.001972782],"category_scores_gemma":[0.00008929108,0.00008639231,0.0001554104,0.00007894779,0.0001683417,0.0001437995,0.0002094016,0.0006340104,0.0002555882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001828407,"about_ca_system_score_gemma":0.0001633179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001410322,"about_ca_topic_score_gemma":0.0003535549,"domain_scores_codex":[0.9999446,0.00001046628,0.000002228833,0.000008107266,0.00001248523,0.00002206212],"domain_scores_gemma":[0.9999717,0.000007744735,0.00000661527,0.000003331344,0.000002666173,0.000008001286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004992126,0.0002086859,0.0001185217,0.0001106156,0.000009448028,0.0001759874,0.00002406175,0.0002932691,0.9836083,0.001635371,0.0006213151,0.01269514],"study_design_scores_gemma":[0.0003061001,0.001976348,0.001458834,0.00002327622,0.00002967439,0.0006038587,0.00005096674,0.002047592,0.9779799,0.0006856608,0.0148242,0.00001340873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9598635,0.01260068,0.01355709,0.001511245,0.0003897012,0.0001815029,0.0002096846,0.0003329207,0.0113537],"genre_scores_gemma":[0.9917671,0.003016813,0.002367242,0.0002453519,0.00004683413,0.00005595051,0.00008498222,0.00001090745,0.002404726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001972782,"threshold_uncertainty_score":0.006599665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03733750850535179,"score_gpt":0.3008112688474663,"score_spread":0.2634737603421146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}