{"id":"W2898378488","doi":"10.1002/jlb.ma0318-112rr","title":"The <i>Salmonella</i> pathogenicity island-2 subverts human NLRP3 and NLRC4 inflammasome responses","year":2018,"lang":"en","type":"article","venue":"Journal of Leukocyte Biology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; Australian Research Council; Medical Research Council; Fonds de Recherche du Québec - Santé; Université de Lausanne; University of Queensland; GlaxoSmithKline Australia; Australian Government; Department of Education and Training; GlaxoSmithKline; Howard Hughes Medical Institute","keywords":"Inflammasome; NLRC4; Pyroptosis; Salmonella; Biology; Pyrin domain; Microbiology; Innate immune system; Immune system; Pathogenicity island; Macrophage; Caspase 1; Cell biology; Immunology; Inflammation; Bacteria; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001465259,0.0002531081,0.0001779388,0.00008783623,0.0000795325,0.0002366213,0.000101878,0.0001892462,0.0008870917],"category_scores_gemma":[0.00009863049,0.00007468182,0.0002609974,0.00007032445,0.0001657953,0.0001123727,0.0001470946,0.0003142126,0.0003317711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001799731,"about_ca_system_score_gemma":0.0001881033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005439545,"about_ca_topic_score_gemma":0.0004754186,"domain_scores_codex":[0.9998586,0.00003300726,0.00001829836,0.00002361754,0.00003168823,0.00003470653],"domain_scores_gemma":[0.9999377,0.000007464482,0.00002247083,0.00001278232,0.000006050354,0.00001347016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006096088,0.00001038114,0.00018689,0.00001089096,0.000002632575,0.00004198079,0.000005496152,0.00001700423,0.9992577,0.00003814642,0.00002995426,0.0003378134],"study_design_scores_gemma":[0.00001218549,0.0002264291,0.006511971,0.000004226324,0.00001090767,0.0008361006,0.00002403893,0.0003180224,0.9900987,0.00004643969,0.001908795,0.00000223034],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969916,0.0005233271,0.001255984,0.00009294542,0.00001696574,0.00001381381,0.0002238083,0.00006056149,0.0008209162],"genre_scores_gemma":[0.9977415,0.0002473258,0.0006729676,0.0000590613,0.000005934136,0.000009965549,0.0003231779,0.0000107759,0.0009293712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008870917,"threshold_uncertainty_score":0.002967656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008024479013825785,"score_gpt":0.2698561576807353,"score_spread":0.2618316786669095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}