{"id":"W2898378488","doi":"10.1002/jlb.ma0318-112rr","title":"The <i>Salmonella</i> pathogenicity island-2 subverts human NLRP3 and NLRC4 inflammasome responses","year":2018,"lang":"en","type":"article","venue":"Journal of Leukocyte Biology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; Australian Research Council; Medical Research Council; Fonds de Recherche du Québec - Santé; Université de Lausanne; University of Queensland; GlaxoSmithKline Australia; Australian Government; Department of Education and Training; GlaxoSmithKline; Howard Hughes Medical Institute","keywords":"Inflammasome; NLRC4; Pyroptosis; Salmonella; Biology; Pyrin domain; Microbiology; Innate immune system; Immune system; Pathogenicity island; Macrophage; Caspase 1; Cell biology; Immunology; Inflammation; Bacteria; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000768928,0.0001761172,0.0002357006,0.00006660301,0.0003752383,0.00003802222,0.0003278726,0.0002165621,0.00001572609],"category_scores_gemma":[0.0002411936,0.0001153938,0.0001439129,0.00006759258,0.0005849916,0.00000944263,0.0001571831,0.0001853519,0.000007857949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001610727,"about_ca_system_score_gemma":0.0001254161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001207431,"about_ca_topic_score_gemma":0.000139468,"domain_scores_codex":[0.9986402,0.0002554276,0.0004893586,0.0001958176,0.00009357338,0.0003255842],"domain_scores_gemma":[0.9989221,0.00006703463,0.0003703356,0.0002880523,0.0002760094,0.00007646703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001010905,0.00002304365,0.01524902,0.000004769053,0.00011449,0.00001094514,0.00009701426,7.054724e-7,0.9771678,0.0002281096,0.00278996,0.003303231],"study_design_scores_gemma":[0.001688012,0.00310115,0.02363981,0.0000171685,0.00004870729,0.0004458982,0.0002025127,0.000005170194,0.4990915,0.0009276848,0.4705609,0.0002715334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924362,0.005701211,0.00009900916,0.0003415926,0.0004039848,0.00008247828,0.000006142242,0.000004452202,0.0009248817],"genre_scores_gemma":[0.9954818,0.002559884,0.00006953666,0.0003394778,0.0008545229,0.000002624505,0.0000110359,0.00001728888,0.0006637703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4780763,"threshold_uncertainty_score":0.4705622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008024479013825785,"score_gpt":0.2698561576807353,"score_spread":0.2618316786669095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}