{"id":"W2898384408","doi":"10.1093/annonc/mdy284.005","title":"Detection of circulating tumor DNA in de novo metastatic castrate sensitive prostate cancer","year":2018,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital","funders":"","keywords":"Medicine; Prostate cancer; Prostatectomy; Oncology; Cancer; Loss of heterozygosity; Internal medicine; Prostate; Cell-free fetal DNA; Pathology; Gene; Allele; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003406761,0.0001961527,0.00027176,0.0008363206,0.0002303134,0.0004884495,0.0002804769,0.000374521,0.001226826],"category_scores_gemma":[0.001383875,0.0001920926,0.00009673083,0.0004732998,0.000347885,0.0001405202,0.0002552404,0.0002980471,0.0002475893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003646257,"about_ca_system_score_gemma":0.0002572462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001611106,"about_ca_topic_score_gemma":0.002197468,"domain_scores_codex":[0.9997539,0.00004004348,0.00002892046,0.00006629986,0.00007397221,0.00003676303],"domain_scores_gemma":[0.9992884,0.000197233,0.0002530504,0.00003627288,0.00009531647,0.000129807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006732513,0.00007198773,0.9378546,0.0001243335,0.00003230923,0.001344638,0.0003269528,0.000184689,0.04719187,0.00006187853,0.0001503972,0.01198306],"study_design_scores_gemma":[0.00003772779,0.0009649448,0.9724538,0.00002306223,0.00004374171,0.009830467,0.0002151245,0.0005122381,0.01483325,0.0000455596,0.0010305,0.000009561576],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985781,0.0008412567,0.0002241144,0.00001922808,0.000004166999,0.00001035277,0.000103185,0.000009136881,0.000210547],"genre_scores_gemma":[0.9993557,0.0001644535,0.0002646051,0.00001856856,0.000005362907,0.000003379,0.0001219382,0.000001680199,0.00006421532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001611106,"threshold_uncertainty_score":0.004104078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0390880378952891,"score_gpt":0.3535415503728291,"score_spread":0.3144535124775401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}