{"id":"W2898390028","doi":"10.1038/s41418-018-0225-1","title":"Mcl-1 and Bcl-xL are essential for survival of the developing nervous system","year":2018,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Research and Development Corporation of Newfoundland and Labrador; Universities Space Research Association","keywords":"Neurogenesis; Biology; Embryonic stem cell; Programmed cell death; Population; Nervous system; Conditional gene knockout; Neural stem cell; Cell fate determination; Neural development; Cell biology; Neuroscience; Apoptosis; Stem cell; Genetics; Gene; Transcription factor; Phenotype; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001989432,0.0002258994,0.0001441302,0.0004538385,0.0003911151,0.0006758599,0.000354448,0.0002564459,0.001218175],"category_scores_gemma":[0.0003340371,0.0001730006,0.0001146479,0.0001712424,0.0003546743,0.0005587438,0.0004111704,0.0005971455,0.0003983841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007738527,"about_ca_system_score_gemma":0.0003963428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006972968,"about_ca_topic_score_gemma":0.001127684,"domain_scores_codex":[0.999838,0.00002352902,0.00001397664,0.00002506548,0.00005597579,0.00004340404],"domain_scores_gemma":[0.9996071,0.0000449043,0.0001412968,0.00002254724,0.0000695583,0.0001144598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004790587,0.00002540544,0.002700129,0.0000875606,0.00001402334,0.0003199271,0.00003861459,0.0002307724,0.9819931,0.003136765,0.0002636172,0.0107111],"study_design_scores_gemma":[0.00004689218,0.0001737855,0.03035374,0.00001663398,0.00003344561,0.001591178,0.0001103949,0.001526005,0.9543664,0.00145739,0.01030816,0.00001591119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9711456,0.01525678,0.008262351,0.0007146925,0.00007678818,0.00001399661,0.0004501454,0.0002682754,0.003811511],"genre_scores_gemma":[0.9941082,0.001268575,0.001789015,0.00004476021,0.00001703708,0.00000732598,0.0002806259,0.00001528191,0.002469165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001218175,"threshold_uncertainty_score":0.005614698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01021001373638411,"score_gpt":0.2182426862973264,"score_spread":0.2080326725609423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}