{"id":"W2898390028","doi":"10.1038/s41418-018-0225-1","title":"Mcl-1 and Bcl-xL are essential for survival of the developing nervous system","year":2018,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Research and Development Corporation of Newfoundland and Labrador; Universities Space Research Association","keywords":"Neurogenesis; Biology; Embryonic stem cell; Programmed cell death; Population; Nervous system; Conditional gene knockout; Neural stem cell; Cell fate determination; Neural development; Cell biology; Neuroscience; Apoptosis; Stem cell; Genetics; Gene; Transcription factor; Phenotype; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007080449,0.00008266443,0.00009242981,0.00001821123,0.000142447,0.00002009736,0.00005879171,0.00009153622,0.000001557041],"category_scores_gemma":[0.00001476373,0.00005915191,0.00003800447,0.00002723667,0.00003421894,0.00000317952,0.00007488555,0.00001789615,2.558596e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006016172,"about_ca_system_score_gemma":0.00001728817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009066655,"about_ca_topic_score_gemma":0.00002856183,"domain_scores_codex":[0.9995106,0.00002588719,0.0001263038,0.0001732485,0.00006438214,0.00009953308],"domain_scores_gemma":[0.9996142,0.000007739502,0.0001120034,0.0001489725,0.0000887478,0.00002827584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008522368,0.00002613343,0.01262511,0.0003664241,0.00002829398,9.875037e-8,0.00009413368,0.000004653611,0.9782333,0.005108051,0.00009887041,0.003329662],"study_design_scores_gemma":[0.001121934,0.0001648883,0.2601439,0.00006897202,0.00009022879,0.000005286728,0.0002211561,0.003198163,0.7327241,0.000685217,0.001381868,0.0001942323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9521391,0.0003216287,0.04674864,0.00003605559,0.0003767814,0.0002051721,0.00001068114,0.000005560329,0.0001563506],"genre_scores_gemma":[0.9988313,0.00008078932,0.0004774848,0.00001537522,0.0002250591,0.000008582571,0.00004812628,0.000008989133,0.0003043298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2475188,"threshold_uncertainty_score":0.2412145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01021001373638411,"score_gpt":0.2182426862973264,"score_spread":0.2080326725609423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}