{"id":"W2898397748","doi":"10.1016/j.cell.2018.09.050","title":"Changes of Cell Biochemical States Are Revealed in Protein Homomeric Complex Dynamics","year":2018,"lang":"en","type":"article","venue":"Cell","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; Université de Montréal","funders":"H2020 European Research Council; Canadian Institutes of Health Research; Cancer Research UK; Human Frontier Science Program; Francis Crick Institute; Wellcome Trust","keywords":"Biology; Bimolecular fluorescence complementation; Homomeric; Longevity; Complementation; Gene; Saccharomyces cerevisiae; Yeast; Computational biology; Genetics; Cell biology; Protein subunit","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009992089,0.0001106787,0.0001409924,0.00005813329,0.00002428227,0.000007812881,0.0002117808,0.000107969,0.00005201547],"category_scores_gemma":[0.00001817173,0.0001037364,0.00003643329,0.0001596278,0.0001879378,8.563138e-7,0.0001607804,0.00008033216,0.00002426292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001506391,"about_ca_system_score_gemma":0.00003736977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002574932,"about_ca_topic_score_gemma":0.0001355182,"domain_scores_codex":[0.9991762,0.000043324,0.0001442381,0.0002532355,0.0001247986,0.0002582033],"domain_scores_gemma":[0.9994739,0.000006540034,0.00006883825,0.0002614794,0.0001198257,0.00006939357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007267506,0.0001289677,0.001585275,0.000130984,0.000004024823,0.000002259741,0.00003023838,0.00000332189,0.9968751,0.000002503581,0.000953545,0.0002111157],"study_design_scores_gemma":[0.0004169118,0.0004071304,0.002313533,0.00001984359,0.000002575032,0.000001042149,0.0001236707,0.0005657782,0.9934964,0.00004957073,0.002480293,0.0001232661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965567,0.0004399393,0.00006929526,0.00009396271,0.00002824014,0.0002208499,0.00006644028,0.000004318317,0.00252025],"genre_scores_gemma":[0.9966081,0.0001399564,0.0008456947,0.00004726681,0.0001074188,0.000020753,0.0001785563,0.00001784215,0.002034352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003378703,"threshold_uncertainty_score":0.4230249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01523660033670666,"score_gpt":0.2587646194851172,"score_spread":0.2435280191484105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}