{"id":"W2898398170","doi":"10.1093/brain/awy264","title":"Atrophy subtypes in prodromal Alzheimer’s disease are associated with cognitive decline","year":2018,"lang":"en","type":"article","venue":"Brain","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":155,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; IXICO; H. Lundbeck A/S; Servier; DoD Alzheimer's Disease Neuroimaging Initiative; Pfizer; Biogen; BioClinica; Alzheimer Nederland; Eisai; ZonMw; European Federation of Pharmaceutical Industries and Associations; National Institute on Aging; National Institute for Health and Care Research; Northern California Institute for Research and Education; F. Hoffmann-La Roche; National Institute on Handicapped Research; University of Southern California; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; University College London Hospitals NHS Foundation Trust; Alzheimer's Disease Neuroimaging Initiative; Bentham-Moxon Trust; Meso Scale Diagnostics; Alzheimer's Association; Stichting Dioraphte; Foundation for the National Institutes of Health","keywords":"Atrophy; Dementia; Cognitive decline; Disease; Alzheimer's disease; Psychology; Cognition; Cognitive reserve; Medicine; Pathology; Internal medicine; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003253756,0.0001388603,0.0002055858,0.0001474546,0.0000661927,0.00002455318,0.00006458027,0.00004550246,0.0004710031],"category_scores_gemma":[0.000979513,0.0001065073,0.00004716961,0.0004009125,0.0002463834,0.00007931196,0.0000645286,0.0001600107,0.0001651066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003770824,"about_ca_system_score_gemma":0.0002082192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003120015,"about_ca_topic_score_gemma":0.0003167199,"domain_scores_codex":[0.9985992,0.0001238394,0.0001579247,0.0003099796,0.0004328155,0.0003762392],"domain_scores_gemma":[0.9990777,0.0001547476,0.00006477709,0.0001229659,0.000343088,0.0002367254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002512791,0.0006474609,0.9908972,0.0000162233,0.0001692016,0.0006548851,0.0001119313,5.377314e-8,0.0002256077,0.00002603759,0.000928357,0.003810282],"study_design_scores_gemma":[0.004429081,0.001370139,0.9914505,0.0004301124,0.0001755739,0.000007214565,0.0001928578,0.00009185094,0.001103077,0.000125374,0.0004889082,0.0001353349],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910616,0.0001777384,0.00004751949,0.004066713,0.00002775642,0.0007899735,0.00003734118,0.00005247672,0.003738915],"genre_scores_gemma":[0.9961257,0.000004487996,0.00004493238,0.001918894,0.000159228,0.00007684511,0.0001301302,0.00002454834,0.001515217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005064152,"threshold_uncertainty_score":0.5157154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02561007419714507,"score_gpt":0.3225417424141589,"score_spread":0.2969316682170139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}