{"id":"W2898398170","doi":"10.1093/brain/awy264","title":"Atrophy subtypes in prodromal Alzheimer’s disease are associated with cognitive decline","year":2018,"lang":"en","type":"article","venue":"Brain","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":155,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; IXICO; H. Lundbeck A/S; Servier; DoD Alzheimer's Disease Neuroimaging Initiative; Pfizer; Biogen; BioClinica; Alzheimer Nederland; Eisai; ZonMw; European Federation of Pharmaceutical Industries and Associations; National Institute on Aging; National Institute for Health and Care Research; Northern California Institute for Research and Education; F. Hoffmann-La Roche; National Institute on Handicapped Research; University of Southern California; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; University College London Hospitals NHS Foundation Trust; Alzheimer's Disease Neuroimaging Initiative; Bentham-Moxon Trust; Meso Scale Diagnostics; Alzheimer's Association; Stichting Dioraphte; Foundation for the National Institutes of Health","keywords":"Atrophy; Dementia; Cognitive decline; Disease; Alzheimer's disease; Psychology; Cognition; Cognitive reserve; Medicine; Pathology; Internal medicine; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001017266,0.0004515755,0.0006568447,0.001288159,0.0005317268,0.000695897,0.000414516,0.0003256565,0.0007354089],"category_scores_gemma":[0.002671387,0.0001912884,0.0007959566,0.0007913667,0.0003540907,0.0003352856,0.0006485617,0.0004291168,0.0002496116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000411018,"about_ca_system_score_gemma":0.0004938643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007386113,"about_ca_topic_score_gemma":0.01938218,"domain_scores_codex":[0.999551,0.00006516612,0.00006679393,0.0001950227,0.00006713335,0.00005480295],"domain_scores_gemma":[0.9987057,0.0002545638,0.0004616691,0.0002213909,0.0002301174,0.0001264813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001018149,0.00005406103,0.9836056,0.0001030993,0.0002913932,0.0001999212,0.0003718175,0.0004609755,0.003532121,0.0001036952,0.0009589847,0.009300177],"study_design_scores_gemma":[0.00002208949,0.00008269781,0.9962826,0.00002426361,0.0001088908,0.0004930712,0.0001940011,0.0009467269,0.0007030393,0.0004603627,0.0006720999,0.00001025688],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996583,0.0003982548,0.000502234,0.00005093801,0.000006547281,0.00002385577,0.002136517,0.00002570976,0.0002730219],"genre_scores_gemma":[0.9916096,0.0001708726,0.001521233,0.00003236227,0.00001288768,0.00004730278,0.006363695,0.00001487619,0.0002271768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007386113,"threshold_uncertainty_score":0.01468623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02561007419714507,"score_gpt":0.3225417424141589,"score_spread":0.2969316682170139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}