{"id":"W2898411672","doi":"10.1002/jbm4.10118","title":"A Multicenter Observational Cohort Study to Evaluate the Effects of Bisphosphonate Exposure on Bone Mineral Density and Other Health Outcomes in Osteogenesis Imperfecta","year":2018,"lang":"en","type":"article","venue":"JBMR Plus","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Shriners Hospitals for Children - Canada; Montreal Children's Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Dental and Craniofacial Research; National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Banting and Best Diabetes Centre, University of Toronto; Intellectual and Developmental Disabilities Research Center; Rare Diseases Clinical Research Network; National Institutes of Health; Osteogenesis Imperfecta Foundation; Doris Duke Charitable Foundation","keywords":"Osteogenesis imperfecta; Bone mineral; Medicine; Cohort; Logistic regression; Osteoporosis; Bone density; Bisphosphonate; Dentistry; Pediatrics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003257151,0.0005611607,0.0007815291,0.0006616423,0.001022086,0.0007951091,0.0008560095,0.0009737205,0.001332678],"category_scores_gemma":[0.004549017,0.0006992168,0.0009972337,0.001211998,0.000246055,0.0005777389,0.0007688774,0.001047071,0.0003080848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005116811,"about_ca_system_score_gemma":0.000757425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01696222,"about_ca_topic_score_gemma":0.01482567,"domain_scores_codex":[0.9981882,0.0008145827,0.0001506398,0.0004197609,0.0002224188,0.0002043571],"domain_scores_gemma":[0.996977,0.0004264883,0.001057881,0.0005278679,0.0003538904,0.0006569193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004899688,0.000165974,0.9980887,0.0000106341,0.0002767008,0.00007732544,0.00007830471,0.00002409298,0.0002345601,0.00003059043,0.0002122474,0.0003108966],"study_design_scores_gemma":[0.0001145941,0.0003827117,0.9984871,0.000007991266,0.0001149464,0.0001558365,0.0001367184,0.0003020799,0.00003694095,0.00002186288,0.0002334693,0.000005748422],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997628,0.0001741197,0.0002065576,0.00005667105,0.00001838375,0.00005293897,0.001617038,0.000005578194,0.0002405539],"genre_scores_gemma":[0.9979044,0.00007746172,0.0002946188,0.00009025644,0.00002311595,0.0000835772,0.001354821,0.000004205029,0.0001674742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01696222,"threshold_uncertainty_score":0.03372699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02302196850700412,"score_gpt":0.3436418602391301,"score_spread":0.320619891732126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}