{"id":"W2898428315","doi":"10.1038/s41385-018-0101-9","title":"Entamoeba histolytica-induced IL-1β secretion is dependent on caspase-4 and gasdermin D","year":2018,"lang":"en","type":"article","venue":"Mucosal Immunology","topic":"Amoebic Infections and Treatments","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Inflammasome; Caspase 1; Entamoeba histolytica; Secretion; Cell biology; Caspase; Pyroptosis; Chemistry; Caspase 3; Biology; Biochemistry; Microbiology; Receptor; Apoptosis; Programmed cell death","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007904417,0.0001719698,0.0002459653,0.0001602227,0.0001825154,0.00001106133,0.00004335704,0.0001874692,0.0008879388],"category_scores_gemma":[0.00004984201,0.0001453003,0.00005422002,0.00009467582,0.0001945294,0.00004739523,0.00005248341,0.0001989788,0.0007654771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002228215,"about_ca_system_score_gemma":0.0000644991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004141302,"about_ca_topic_score_gemma":0.00006658866,"domain_scores_codex":[0.999037,0.0000513509,0.000188182,0.0003238735,0.0001119878,0.0002875717],"domain_scores_gemma":[0.9993917,0.00004552877,0.00006392424,0.0003307725,0.00008820621,0.00007982294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004504112,0.004768744,0.1006188,0.0001350634,0.003139961,0.002096796,0.005152912,3.003421e-7,0.5937455,0.01624891,0.01235818,0.2572307],"study_design_scores_gemma":[0.01913797,0.02237441,0.5168288,0.0002494197,0.001169539,0.008100229,0.001021031,0.000568099,0.362382,0.002061459,0.06505828,0.001048779],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848979,0.0001599761,0.0001124946,0.001292123,0.0006060128,0.0002745038,0.00001167018,0.0000771084,0.01256822],"genre_scores_gemma":[0.9959999,0.00006026288,0.0001559912,0.0009344631,0.000169295,0.00002997544,0.00003233345,0.00002259009,0.002595138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.41621,"threshold_uncertainty_score":0.9838914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02029564953847898,"score_gpt":0.2856362548500634,"score_spread":0.2653406053115844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}