{"id":"W2898455197","doi":"10.3390/cancers10110397","title":"DNA Methylation Predicts the Response of Triple-Negative Breast Cancers to All-Trans Retinoic Acid","year":2018,"lang":"en","type":"article","venue":"Cancers","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Killam Trusts; Dalhousie University; Nova Scotia Health Research Foundation; Canadian Imperial Bank of Commerce; Cancer Research Institute; Health Sciences Centre Foundation; QEII Foundation; Dalhousie Medical Research Foundation; Breast Cancer Society of Canada; Beatrice Hunter Cancer Research Institute","keywords":"Triple-negative breast cancer; DNA methylation; Cancer research; Retinoic acid; Acute promyelocytic leukemia; Retinoic acid receptor; Methylation; Biology; Tretinoin; Breast cancer; Gene expression; Molecular biology; Chemistry; Cell culture; Cancer; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005372175,0.0001309633,0.0001275141,0.00004953719,0.0000901664,0.00001185424,0.0001967219,0.0001111581,0.00004175009],"category_scores_gemma":[0.0002387019,0.000106214,0.00007109491,0.0002114258,0.0001980906,0.000004408104,0.00003829032,0.00006360805,0.000004563062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002290198,"about_ca_system_score_gemma":0.000541846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000334185,"about_ca_topic_score_gemma":0.000586769,"domain_scores_codex":[0.9989008,0.0001972292,0.0002239035,0.0002891308,0.0001770987,0.0002118017],"domain_scores_gemma":[0.999149,0.0000385318,0.0001249966,0.0003597517,0.0002315787,0.00009609509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001562752,0.000003730185,0.0002642011,0.000006975825,0.00006559379,2.644657e-7,0.0009659023,0.000816443,0.9914588,0.00001245603,0.001535557,0.003307304],"study_design_scores_gemma":[0.0004884232,0.0006317854,0.01105632,0.00002000542,0.00003400279,0.000001108613,0.0001959665,0.0001891927,0.9679587,0.00007776851,0.01921687,0.0001298291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923094,0.0006882912,0.004436029,0.0006193931,0.0004421064,0.0003941261,0.0001358043,0.000009663802,0.000965199],"genre_scores_gemma":[0.9981897,0.0001987494,0.0004589626,0.0003583402,0.000330875,0.00004211177,0.00003196544,0.00001988901,0.0003693943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02350009,"threshold_uncertainty_score":0.433128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01561680084210279,"score_gpt":0.2858873351062887,"score_spread":0.270270534264186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}