{"id":"W2898455197","doi":"10.3390/cancers10110397","title":"DNA Methylation Predicts the Response of Triple-Negative Breast Cancers to All-Trans Retinoic Acid","year":2018,"lang":"en","type":"article","venue":"Cancers","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Killam Trusts; Dalhousie University; Nova Scotia Health Research Foundation; Canadian Imperial Bank of Commerce; Cancer Research Institute; Health Sciences Centre Foundation; QEII Foundation; Dalhousie Medical Research Foundation; Breast Cancer Society of Canada; Beatrice Hunter Cancer Research Institute","keywords":"Triple-negative breast cancer; DNA methylation; Cancer research; Retinoic acid; Acute promyelocytic leukemia; Retinoic acid receptor; Methylation; Biology; Tretinoin; Breast cancer; Gene expression; Molecular biology; Chemistry; Cell culture; Cancer; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002342294,0.000169087,0.000270148,0.0005138561,0.00009739948,0.0002329807,0.00009911331,0.0002858688,0.001038334],"category_scores_gemma":[0.0006736384,0.0001182958,0.000151392,0.0002421573,0.0001114714,0.00009878918,0.0001434462,0.0003372564,0.0002166599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001759882,"about_ca_system_score_gemma":0.000104858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001900841,"about_ca_topic_score_gemma":0.002542306,"domain_scores_codex":[0.999878,0.00002357353,0.00001267379,0.00003025655,0.00003103186,0.0000245379],"domain_scores_gemma":[0.9997281,0.00009256347,0.00007435726,0.0000170894,0.00003838777,0.0000494788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001130494,0.00009349887,0.6513078,0.00003739995,0.0001165475,0.0001132689,0.0001029414,0.001586253,0.3302101,0.00005739915,0.0001857202,0.01505844],"study_design_scores_gemma":[0.00001479794,0.0003936969,0.9491228,0.000007736277,0.00008580882,0.0007118376,0.0001342467,0.00608085,0.04260571,0.0001365278,0.0006979785,0.000007970389],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986558,0.0002882648,0.0004438465,0.00003380073,0.000002627072,0.000006914876,0.0001713325,0.00001183761,0.0003855942],"genre_scores_gemma":[0.9990287,0.0001400769,0.0003470992,0.00001681286,0.000002448728,0.000005867149,0.0002490432,0.000001992686,0.0002079547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001900841,"threshold_uncertainty_score":0.00377959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01561680084210279,"score_gpt":0.2858873351062887,"score_spread":0.270270534264186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}