{"id":"W2898456045","doi":"10.1016/j.bmcl.2018.10.044","title":"Stability and evaluation of siRNAs labeled at the sense strand with a 3′-azobenzene unit","year":2018,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Tech University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Nuclease; Chemistry; Azobenzene; Gene silencing; Sense (electronics); Small interfering RNA; Stereochemistry; RNA; Gene; Biophysics; Photochemistry; Biochemistry; Organic chemistry; Molecule; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004672828,0.0002193586,0.0001601582,0.0001849889,0.0002710461,0.0002680066,0.00016951,0.0002458981,0.001113664],"category_scores_gemma":[0.0006133035,0.0001348673,0.000265989,0.0001814287,0.0002546515,0.0001794746,0.0001046015,0.0002681843,0.0003862961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004286267,"about_ca_system_score_gemma":0.0002476231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002984178,"about_ca_topic_score_gemma":0.002522067,"domain_scores_codex":[0.9997444,0.00005491809,0.00002790864,0.00006339433,0.00006450291,0.00004493275],"domain_scores_gemma":[0.999472,0.0001633543,0.00009267134,0.00004684975,0.0001894836,0.00003568249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000630559,0.000006418019,0.000112945,0.000009918161,0.000003296308,0.000009809493,0.00002415869,0.00005056195,0.9992926,0.00002797995,0.00001339159,0.000385865],"study_design_scores_gemma":[0.000001844251,0.00008176698,0.0006918381,5.163691e-7,0.000007767391,0.00001511375,0.000006487454,0.0002857494,0.9986946,0.000005542101,0.000206068,0.000002704678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993347,0.0006705798,0.004230316,0.00005493289,0.00002545706,0.00001759214,0.0003456192,0.00005780486,0.001250626],"genre_scores_gemma":[0.9945908,0.0003222068,0.002012221,0.00002818802,0.000008144872,0.0000262649,0.0005163345,0.00003362102,0.002462381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002984178,"threshold_uncertainty_score":0.005933583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02462653442877819,"score_gpt":0.2587142672811307,"score_spread":0.2340877328523525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}