{"id":"W2898464095","doi":"10.1016/j.cgh.2018.10.036","title":"Infliximab Exposure-Response Relationship and Thresholds Associated With Endoscopic Healing in Patients With Ulcerative Colitis","year":2018,"lang":"en","type":"article","venue":"Clinical Gastroenterology and Hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Robarts Clinical Trials","funders":"UCB Pharma; Janssen Biotech; School of Public Health, University of California Berkeley; Atlantic Healthcare; Crohn's and Colitis Foundation; UCB; Prometheus; Takeda Pharmaceuticals U.S.A.; Bristol-Myers Squibb; Shire; Tillotts Pharma; Crohn's and Colitis Foundation of Canada; Seres Therapeutics; Boehringer Ingelheim; Janssen Pharmaceuticals; Gilead Sciences; Western University; AbbVie; Merck; Biogen","keywords":"Infliximab; Medicine; Ulcerative colitis; Gastroenterology; Internal medicine; Placebo; Therapeutic drug monitoring; Pharmacokinetics; Population; Randomized controlled trial; Colonoscopy; Surgery; Tumor necrosis factor alpha; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006697946,0.0002404848,0.0005656026,0.0008275317,0.0003254296,0.0009470631,0.0002674634,0.000888689,0.001780551],"category_scores_gemma":[0.004654143,0.000234725,0.0005629535,0.001214299,0.0003087684,0.0005714872,0.0004267256,0.00105779,0.0003227397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002499298,"about_ca_system_score_gemma":0.0001810117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005958783,"about_ca_topic_score_gemma":0.0006459277,"domain_scores_codex":[0.9992168,0.0002503552,0.0001407727,0.0001392333,0.0001116767,0.0001410602],"domain_scores_gemma":[0.9949668,0.001985723,0.002019576,0.0002336276,0.0001980196,0.0005961686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009371591,0.00006589884,0.9964323,0.00001121963,0.00005998956,0.0001958305,0.00005681729,0.00005013688,0.0005215551,0.00002109804,0.00003449658,0.001613616],"study_design_scores_gemma":[0.000009942218,0.0001538072,0.9990261,0.00000367441,0.00003411237,0.000350285,0.00008218139,0.0001684374,0.00006464699,0.00003480147,0.00006801767,0.000004075222],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987836,0.000516351,0.00007389895,0.00005444281,0.000006464649,0.000003177855,0.00005984919,0.000005116017,0.0004971271],"genre_scores_gemma":[0.9996933,0.00005621853,0.00005673364,0.00002106758,0.00001210765,0.000002392855,0.00007180735,0.000001867883,0.00008443425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001780551,"threshold_uncertainty_score":0.005956471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01419601897389679,"score_gpt":0.2764460897538591,"score_spread":0.2622500707799624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}