{"id":"W2898487027","doi":"10.15252/embr.201846303","title":"ADAR1‐mediated RNA editing is required for thymic self‐tolerance and inhibition of autoimmunity","year":2018,"lang":"en","type":"article","venue":"EMBO Reports","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Genetics; Ministry of Education, Culture, Sports, Science and Technology; Japan Society for the Promotion of Science; Mochida Memorial Foundation for Medical and Pharmaceutical Research; SENSHIN Medical Research Foundation; Takeda Science Foundation","keywords":"ADAR; Autoimmunity; RNA; RNA-binding protein; RNA editing; Biology; Genome editing; Cell biology; Immunology; Computational biology; Genetics; Antibody; Gene; CRISPR","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000176325,0.00007639286,0.00009882294,0.00002311353,0.00008043644,0.000009930267,0.00002369982,0.00008118412,0.00002115426],"category_scores_gemma":[0.000161382,0.00007609437,0.00004717116,0.00004815551,0.00008585831,0.000006395284,0.00003324356,0.00002261015,9.16817e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005937908,"about_ca_system_score_gemma":0.00006303527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001160996,"about_ca_topic_score_gemma":0.000004925766,"domain_scores_codex":[0.9993455,0.00001981877,0.0002511648,0.0001939078,0.00008226807,0.0001073303],"domain_scores_gemma":[0.9993105,0.000007274761,0.0002222098,0.000229706,0.0001741695,0.00005612588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007401626,0.00006469653,0.006627562,0.0000600106,0.00002808313,0.000007956465,0.0001942014,0.000003070374,0.9836168,0.00002737657,0.008052939,0.001243307],"study_design_scores_gemma":[0.0008988717,0.0002937405,0.05485125,0.00006410553,0.00003812048,0.00006035183,0.00009041939,0.0008661007,0.9130589,0.0006668838,0.02888745,0.0002237612],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974944,0.0002452559,0.0004989292,0.000127594,0.0001800818,0.0001740934,0.00001951876,0.00001989453,0.001240215],"genre_scores_gemma":[0.9984054,0.00001755708,0.0006258055,0.0002358401,0.0002850335,0.00001317893,0.0001642243,0.00001054948,0.0002424184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07055783,"threshold_uncertainty_score":0.3103038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01021224384112209,"score_gpt":0.2546054439151337,"score_spread":0.2443932000740116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}