{"id":"W2898487027","doi":"10.15252/embr.201846303","title":"ADAR1‐mediated RNA editing is required for thymic self‐tolerance and inhibition of autoimmunity","year":2018,"lang":"en","type":"article","venue":"EMBO Reports","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Genetics; Ministry of Education, Culture, Sports, Science and Technology; Japan Society for the Promotion of Science; Mochida Memorial Foundation for Medical and Pharmaceutical Research; SENSHIN Medical Research Foundation; Takeda Science Foundation","keywords":"ADAR; Autoimmunity; RNA; RNA-binding protein; RNA editing; Biology; Genome editing; Cell biology; Immunology; Computational biology; Genetics; Antibody; Gene; CRISPR","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003841639,0.0003852246,0.0003922586,0.0002670843,0.0002918444,0.001011431,0.0005489473,0.0005694458,0.001864112],"category_scores_gemma":[0.0003264106,0.0003615003,0.0003581463,0.0001111186,0.0004135827,0.0003398711,0.000384656,0.0009285051,0.001338668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003727992,"about_ca_system_score_gemma":0.0001831981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001578641,"about_ca_topic_score_gemma":0.0003067264,"domain_scores_codex":[0.9996119,0.00004962274,0.00003413121,0.0001261845,0.00009458684,0.00008357271],"domain_scores_gemma":[0.9995543,0.00004354839,0.0001620218,0.00007433541,0.00003414421,0.0001315677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001290666,0.00001103714,0.0003531854,0.00002142215,0.000006400083,0.0001291606,0.000008573499,0.00004987088,0.9979064,0.0001373543,0.0000732464,0.001174148],"study_design_scores_gemma":[0.00002875199,0.0001107824,0.0125124,0.000005994734,0.00002675189,0.001724157,0.00003337287,0.001291727,0.9803185,0.0002235269,0.003714241,0.000009854657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98385,0.003673522,0.007185869,0.0003376195,0.0001685126,0.00001829217,0.0003962513,0.0006920449,0.003677925],"genre_scores_gemma":[0.9957904,0.0002927223,0.001668251,0.00005775599,0.00002502069,0.000006984014,0.00027747,0.00007887226,0.00180242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001864112,"threshold_uncertainty_score":0.006236076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01021224384112209,"score_gpt":0.2546054439151337,"score_spread":0.2443932000740116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}