{"id":"W2898524268","doi":"10.1016/j.neurobiolaging.2018.10.019","title":"A comprehensive screening of copy number variability in dementia with Lewy bodies","year":2018,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Genomic variations and chromosomal abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Occupational Cancer Research Centre; Canada Research Chairs; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Human Genome Research Institute; NIHR Oxford Biomedical Research Centre; National Health and Medical Research Council; National Center for Advancing Translational Sciences; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Johns Hopkins University; Folkhälsanin Tutkimussäätiö; University College London Hospitals NHS Foundation Trust; Samfundet Folkhälsan; University of California, San Diego; Helene Morgan Babcock and Alfred Babcock Memorial Scholarship Trust; University of New South Wales; Parkinson's UK; Generalitat de Catalunya; National Institute on Aging; National Institute for Health and Care Research; Alzheimer's Society; Alzheimer Society; Helsingin ja Uudenmaan Sairaanhoitopiiri; Centres de Recerca de Catalunya; Michael J. Fox Foundation for Parkinson's Research; National Institute on Drug Abuse; University of Pennsylvania; Little Family Foundation; Neuroscience Research Australia; Consortium canadien en neurodégénérescence associée au vieillissement; Parkinson's Disease Foundation; Agence Nationale de la Recherche; Wellcome Trust; Krembil Foundation; Alzheimer's Disease Research Center, University of Pittsburgh; U.S. Department of Health and Human Services","keywords":"Dementia with Lewy bodies; Copy-number variation; Genome-wide association study; Genotyping; Disease; Dementia; Locus (genetics); Genetic association; Genetics; Medicine; Biology; Genome; Gene; Single-nucleotide polymorphism; Genotype; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000129654,0.00009082926,0.0001686209,0.00002943395,0.00003733109,0.000002611191,0.0001029878,0.00006189065,0.00004155541],"category_scores_gemma":[0.00001613128,0.00008046901,0.00003286591,0.00004781024,0.0003214184,0.000003393995,0.00009430738,0.00005172578,0.000001433892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002934406,"about_ca_system_score_gemma":0.000032319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009785991,"about_ca_topic_score_gemma":0.00006502245,"domain_scores_codex":[0.9992812,0.000120454,0.0002165735,0.0002011996,0.00003220792,0.0001483376],"domain_scores_gemma":[0.9995235,0.00003273722,0.0001156391,0.0001839179,0.0001282481,0.00001597601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009685631,0.00004533979,0.8155138,0.00004151009,0.00008309261,7.190578e-7,0.0002708979,0.0000956748,0.1834642,0.0002123593,0.0000518489,0.0001237589],"study_design_scores_gemma":[0.0008085943,0.0005478275,0.3351092,0.00003821265,0.00003490799,0.0000255381,0.000331646,0.00003003267,0.6614314,0.0001376828,0.001353921,0.0001510616],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975868,0.00004203765,0.001143688,0.00005029585,0.0000523927,0.00007756317,0.00001509925,0.00000405772,0.001028036],"genre_scores_gemma":[0.996197,0.00001523449,0.003590056,0.00008693233,0.00004398238,0.000004327298,0.00002462159,0.000007118461,0.00003065686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4804046,"threshold_uncertainty_score":0.3281431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01057941190054076,"score_gpt":0.2399549818103594,"score_spread":0.2293755699098187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}