{"id":"W2898544952","doi":"10.1016/j.cell.2018.09.051","title":"Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer","year":2018,"lang":"en","type":"article","venue":"Cell","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":228,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Van Andel Research Institute; National Science Foundation of Sri Lanka; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; F. M. Kirby Foundation; American Association for Cancer Research","keywords":"Biology; P-TEFb; Gene silencing; Epigenetics; Molecular biology; Gene expression; Cancer cell; Gene; Cancer research; Cancer; Genetics; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008921202,0.00009589981,0.00008529711,0.00001907561,0.00004243768,0.0000111186,0.0001172863,0.00009338968,0.0001017802],"category_scores_gemma":[0.00002569347,0.00008967199,0.00003233536,0.00006140482,0.0000653559,0.000001563483,0.0000525186,0.00005169732,0.00002168515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001589551,"about_ca_system_score_gemma":0.00007127992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001311477,"about_ca_topic_score_gemma":0.00006026676,"domain_scores_codex":[0.9992938,0.00002291594,0.0001448625,0.000261229,0.00006791259,0.0002092465],"domain_scores_gemma":[0.9996741,0.000006980777,0.00004056599,0.00016981,0.00006433209,0.00004414467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002134669,0.0000258631,0.00235293,0.00001325519,0.000004290167,7.644028e-7,0.00005781067,0.0003270405,0.9924195,0.00000141263,0.0008529025,0.003922855],"study_design_scores_gemma":[0.0002423597,0.0000862858,0.0008015129,0.00001977362,0.000004082905,6.500354e-7,0.00006149519,0.001166041,0.9843903,0.00004755252,0.013042,0.0001379071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926323,0.003553735,0.0005746873,0.0000612006,0.0001752938,0.00007002994,0.000004478073,0.00001043349,0.002917886],"genre_scores_gemma":[0.9962301,0.001036871,0.001188107,0.0001835299,0.0005498265,0.00001924561,0.00001789895,0.00001714512,0.000757309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0121891,"threshold_uncertainty_score":0.3656718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01089041962498453,"score_gpt":0.2698352215218477,"score_spread":0.2589448018968631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}