{"id":"W2898544952","doi":"10.1016/j.cell.2018.09.051","title":"Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer","year":2018,"lang":"en","type":"article","venue":"Cell","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":228,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Van Andel Research Institute; National Science Foundation of Sri Lanka; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; F. M. Kirby Foundation; American Association for Cancer Research","keywords":"Biology; P-TEFb; Gene silencing; Epigenetics; Molecular biology; Gene expression; Cancer cell; Gene; Cancer research; Cancer; Genetics; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000229879,0.0002472359,0.0002598713,0.0002852597,0.0002283684,0.000544619,0.00039483,0.0002893948,0.003458598],"category_scores_gemma":[0.0002193274,0.0002054272,0.0002094839,0.000162755,0.0003324829,0.0002456553,0.000240888,0.000570013,0.0008142816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005576079,"about_ca_system_score_gemma":0.0002724791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008698335,"about_ca_topic_score_gemma":0.002383002,"domain_scores_codex":[0.9998515,0.00002157856,0.00001294204,0.0000319377,0.00003744454,0.00004463107],"domain_scores_gemma":[0.9999231,0.00001831361,0.00001352802,0.0000182136,0.000007429567,0.00001947994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003256668,0.00006846897,0.0004425165,0.00005121433,0.00001742726,0.00009591585,0.000009203853,0.0003966541,0.9904327,0.0007944214,0.0003282724,0.007037433],"study_design_scores_gemma":[0.00001462782,0.00009462771,0.0008169319,0.000001913818,0.000009771279,0.0001581736,0.0000108274,0.0005931905,0.9947373,0.00008737572,0.003473029,0.000002303519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705997,0.008848364,0.008416589,0.0009348547,0.0003620648,0.00004978491,0.0006924576,0.0006204992,0.009475638],"genre_scores_gemma":[0.99378,0.001448576,0.0008728814,0.00006716443,0.00001513199,0.000009487393,0.0001458853,0.00004199934,0.003618862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003458598,"threshold_uncertainty_score":0.01157016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01089041962498453,"score_gpt":0.2698352215218477,"score_spread":0.2589448018968631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}