{"id":"W2898562166","doi":"10.1039/c8dt03079k","title":"<i>In vitro</i> and <i>in vivo</i> antiproliferative activity of organo-nickel SCS-pincer complexes on estrogen responsive MCF7 and MC4L2 breast cancer cells. Effects of amine fragment substitutions on BSA binding and cytotoxicity","year":2018,"lang":"en","type":"article","venue":"Dalton Transactions","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Iran National Science Foundation","keywords":"Pincer movement; In vivo; In vitro; Amine gas treating; Chemistry; Nickel; Estrogen; Breast cancer; Cancer research; Combinatorial chemistry; Stereochemistry; Biochemistry; Medicinal chemistry; Cancer; Biology; Medicine; Organic chemistry; Internal medicine; Endocrinology; Genetics; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001879661,0.0002242128,0.0005647715,0.0002870448,0.000165754,0.00001311854,0.00004638941,0.0000884591,0.00007752774],"category_scores_gemma":[0.00002705692,0.0001833391,0.00005345222,0.0002780241,0.0005545554,0.0001380789,0.00001216742,0.0002229593,0.00000149779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007667703,"about_ca_system_score_gemma":0.00007964834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007849063,"about_ca_topic_score_gemma":0.0004476384,"domain_scores_codex":[0.9987258,0.0001770961,0.0002995098,0.0003628947,0.0002099521,0.0002247864],"domain_scores_gemma":[0.9991473,0.0003455428,0.0001158779,0.0001953341,0.00008458452,0.0001113515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003404387,0.000461188,0.001376809,0.0003476082,0.00007796829,0.000006030612,0.0007355842,0.00001787318,0.9927433,0.00007481559,0.00001712478,0.0007373673],"study_design_scores_gemma":[0.001581202,0.0006490938,0.03129459,0.0005327011,0.0001097589,0.00002501835,0.0001074419,0.0002996211,0.9651515,0.00001520078,0.00008715178,0.0001467487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972343,0.0003370914,0.0003281192,0.0005737785,0.00007979734,0.000689486,0.0006251344,0.00001136773,0.000120925],"genre_scores_gemma":[0.9987432,0.0006542491,0.000241036,0.0001544344,0.00003455228,0.00005309859,0.000003725444,0.00001731527,0.00009841349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02991778,"threshold_uncertainty_score":0.7476352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01791126973697376,"score_gpt":0.2663350967281433,"score_spread":0.2484238269911695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}