{"id":"W2898562166","doi":"10.1039/c8dt03079k","title":"<i>In vitro</i> and <i>in vivo</i> antiproliferative activity of organo-nickel SCS-pincer complexes on estrogen responsive MCF7 and MC4L2 breast cancer cells. Effects of amine fragment substitutions on BSA binding and cytotoxicity","year":2018,"lang":"en","type":"article","venue":"Dalton Transactions","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Iran National Science Foundation","keywords":"Pincer movement; In vivo; In vitro; Amine gas treating; Chemistry; Nickel; Estrogen; Breast cancer; Cancer research; Combinatorial chemistry; Stereochemistry; Biochemistry; Medicinal chemistry; Cancer; Biology; Medicine; Organic chemistry; Internal medicine; Endocrinology; Genetics; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008899916,0.0002354708,0.0001751313,0.0001399571,0.00007283725,0.0001208092,0.0001744764,0.0001570506,0.0008490555],"category_scores_gemma":[0.00008310538,0.00007279891,0.0001200082,0.0001145577,0.0001044421,0.00008769563,0.00008802338,0.0001366938,0.0001631055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001883814,"about_ca_system_score_gemma":0.00008955278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009674932,"about_ca_topic_score_gemma":0.001211789,"domain_scores_codex":[0.9999257,0.00001710018,0.000006024695,0.00001351673,0.00002034213,0.00001716996],"domain_scores_gemma":[0.9999602,0.000007741131,0.00001188839,0.000003330613,0.000009869777,0.000006899526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001827173,0.00001242205,0.0001231825,0.00005940082,0.000004997709,0.0000336564,0.00001187262,0.0001187589,0.9982969,0.00003986089,0.00006346014,0.001052844],"study_design_scores_gemma":[0.000003578149,0.0002456064,0.0007084198,0.00000259611,0.000008945862,0.00006240405,0.00000810187,0.0002087687,0.997978,0.000005801774,0.000765789,0.000001924293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927106,0.002346137,0.0011878,0.000065395,0.00001565352,0.00001797622,0.0003024899,0.00008049179,0.00327357],"genre_scores_gemma":[0.9956545,0.0009332541,0.0008647417,0.0000457685,0.000004977308,0.00002070681,0.0004439944,0.00001089876,0.002021236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009674932,"threshold_uncertainty_score":0.0028404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01791126973697376,"score_gpt":0.2663350967281433,"score_spread":0.2484238269911695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}