{"id":"W2898576573","doi":"10.1101/455683","title":"Altered BOLD signal variation in Alzheimer’s disease and frontotemporal dementia","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cerebrospinal fluid and hydrocephalus","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; IXICO; H. Lundbeck A/S; Servier; National Institutes of Health; Pohjois-Pohjanmaan Rahasto; Epilepsiatutkimussäätiö; Orionin Tutkimussäätiö; Eisai; Suomen Kulttuurirahasto; Northern California Institute for Research and Education; Alzheimer's Disease Neuroimaging Initiative; Suomen Lääketieteen Säätiö; F. Hoffmann-La Roche; Pfizer; Biogen; BioClinica; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Frontotemporal dementia; Atrophy; Precuneus; Neuroscience; Neuroimaging; Dementia; Psychology; White matter; Early-onset Alzheimer's disease; Medicine; Disease; Pathology; Audiology; Cognition; Magnetic resonance imaging; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006856936,0.000326144,0.0003098696,0.001156514,0.0002166372,0.0004065959,0.0001776165,0.0003737865,0.0009910403],"category_scores_gemma":[0.001699229,0.0001507349,0.0001560618,0.0003649648,0.0002790076,0.0002199798,0.0002359897,0.0001770339,0.0001349256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001866095,"about_ca_system_score_gemma":0.00009062074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001951689,"about_ca_topic_score_gemma":0.002049874,"domain_scores_codex":[0.9998125,0.00003730838,0.00002098869,0.0000524762,0.00004864794,0.00002811309],"domain_scores_gemma":[0.999414,0.0001713096,0.0002256707,0.00003918713,0.00007453735,0.00007533927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00316054,0.0001610072,0.9437726,0.00008396151,0.0002318192,0.001951421,0.0005218898,0.0003202914,0.03449811,0.0001049465,0.0003666118,0.01482682],"study_design_scores_gemma":[0.000006027967,0.00008926196,0.9982034,0.00000287903,0.0000178206,0.0006672485,0.00004469966,0.0002407179,0.0005779621,0.00008777372,0.00005975934,0.00000244455],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992865,0.0001986157,0.0001350975,0.0000183072,0.00000364534,0.000002996242,0.00007175124,0.000007106415,0.0002760437],"genre_scores_gemma":[0.9996265,0.00005124817,0.0001358257,0.00001043662,0.000006709826,0.000002348601,0.0000934627,0.000001556995,0.00007197099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001951689,"threshold_uncertainty_score":0.00388068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02739996816143236,"score_gpt":0.2434109242615743,"score_spread":0.216010956100142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}