{"id":"W2898585601","doi":"10.1038/s41467-018-08054-4","title":"Shared heritability and functional enrichment across six solid cancers","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Memorial University of Newfoundland; University of Alberta; Sinai Health System; University of British Columbia; McGill University; Canada Research Chairs; Queen's University; BC Cancer Agency; Vancouver General Hospital; Princess Margaret Cancer Centre; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Centre hospitalier universitaire de Québec; Royal Victoria Hospital; University Health Network; University of Toronto","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Medical Research and Materiel Command; National Institute of Diabetes and Digestive and Kidney Diseases; Fogarty International Center; National Institute of General Medical Sciences; National Human Genome Research Institute; National Institute on Drug Abuse; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Aging; Servicio Gallego de Salud; Ontario Ministry of Research and Innovation; National Cancer Institute; European Regional Development Fund; Instituto de Salud Carlos III; Cancer Council NSW; Cancer Council Victoria; Canadian Cancer Society Research Institute; Norris Cotton Cancer Center; U.S. Army; Hellenic Health Foundation; Freistaat Sachsen; Biomedical Research Council; Federal Agency for Scientific Organizations; Pomorski Uniwersytet Medyczny W Szczecinie; Mutuelle Générale de l'Education Nationale; Institut Gustave-Roussy; Ministero dello Sviluppo Economico; Universidad de Oviedo; Center for Agroforestry, University of Missouri; Oulun Yliopisto; KWF Kankerbestrijding; Conseil Régional des Pays de la Loire; Vetenskapsrådet; National Medical Research Council; Norges Forskningsråd; Stockholms Läns Landsting; Stavros Niarchos Foundation; Ligue Contre le Cancer; Kuopion Yliopistollinen Sairaala; Associazione Italiana per la Ricerca sul Cancro; Karolinska Institutet; Vanderbilt University; Korea Health Industry Development Institute; Hungarian Scientific Research Fund; Japan Agency for Medical Research and Development; Deutsche Gesetzliche Unfallversicherung; Herlev Hospital; National Institute of Environmental Health Sciences; Swedish Cancer Foundation; Ministry of Health, Labour and Welfare; University of Southern California; Cancerfonden; American Cancer Society; Radboud Universiteit; Cancer Australia; Russian Foundation for Basic Research; National Health and Medical Research Council; Deutsche Krebshilfe; Ministry of Education, Science and Technology; Academia Sinica; California Department of Public Health; National Research Foundation of Korea; National Natural Science Foundation of China; Departament d'Universitats, Recerca i Societat de la Informació; Institut National de la Santé et de la Recherche Médicale; Programme Grants for Applied Research; Ovarian Cancer Australia; Robert Bosch Stiftung; Fisher Center for Alzheimer's Research Foundation; Prostate Cancer Foundation of Australia; Fundação de Amparo à Pesquisa do Estado de São Paulo; Canadian Institutes of Health Research; European Commission; Medizinischen Hochschule Hannover; Cancer Institute NSW; University College London; Academy of Finland; King's College London; Lon V. Smith Foundation; Deutscher Akademischer Austauschdienst; Health Canada; Instytut Medycyny Pracy im. prof. J. Nofera; Yayasan Sime Darby; National Institute of Dental and Craniofacial Research; University of Cambridge; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal; Virginia Department of Health; Government of Canada; Genome Canada; Fred C. and Katherine B. Andersen Foundation; Georgia Clinical and Translational Science Alliance; Royal Marsden NHS Foundation Trust; Wellcome Trust; Johns Hopkins University; Ontario Institute for Cancer Research; World Cancer Research Fund; BC Cancer Foundation; Cancer Care Ontario; Cancer Research Society; Institute of Biomedical Sciences, Academia Sinica; David F. and Margaret T. Grohne Family Foundation; Cancer Prevention and Research Institute of Texas; Helse Vest; Association Anne de Bretagne Genetique; Cancer Council South Australia; Memorial Sloan-Kettering Cancer Center; Centre International de Recherche sur le Cancer; Kreftforeningen; Sundhed og Sygdom, Det Frie Forskningsråd; Vanderbilt University Medical Center; Deutsches Krebsforschungszentrum; Peter MacCallum Foundation; Fundación para el Fomento en Asturias de la Investigación Científica Aplicada y la Tecnología; Helsingin ja Uudenmaan Sairaanhoitopiiri; Kræftens Bekæmpelse; Dr. Ralph and Marian Falk Medical Research Trust; Roswell Park Cancer Institute; Compagnia di San Paolo; National Institutes of Health; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Florida Department of Health; Division of Cancer Prevention, National Cancer Institute; National Breast Cancer Foundation; European Social Fund; Medical Research Council; Mayo Foundation for Medical Education and Research; Rutgers Cancer Institute of New Jersey; Junta de Castilla y León; Susan G. Komen for the Cure; Taiwan Biobank; Prostate Cancer Foundation; Oak Foundation; National Center for Research Resources; Avon Foundation for Women; World Health Organization; University of South Florida; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; National Research Foundation; Centers for Disease Control and Prevention; National Institute for Health and Care Research; National Cancer Research Institute; U.S. Department of Health and Human Services; Ministerio de Economía y Competitividad; National Center for Advancing Translational Sciences; Bundesministerium für Bildung und Forschung; Ministry of Education, Culture, Sports, Science and Technology; Japan Society for the Promotion of Science; Ovarian Cancer Research Fund; Breast Cancer Campaign; Georgetown University; Cancer Council Tasmania; Itä-Suomen Yliopisto; Agency for Science, Technology and Research; State of Connecticut Department of Public Health; Cancer Research Institute; Oregon Health and Science University; Cancer Research UK; Sheffield Hospitals Charity; NordForsk; U.S. Department of Defense; University of Pittsburgh; Breast Cancer Research Foundation; University of Texas MD Anderson Cancer Center; Princess Margaret Hospital Foundation; Moffitt Cancer Center; Minnesota Ovarian Cancer Alliance; Fonds Wetenschappelijk Onderzoek; Roy Castle Lung Cancer Foundation; California Breast Cancer Research Program; Fondation du cancer du sein du Québec","keywords":"Heritability; Computational biology; Biology; Genetics; Evolutionary biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000189114,0.00008632937,0.00008110949,0.00001295083,0.0001593969,0.00002943239,0.0002309163,0.0002218436,0.00002379492],"category_scores_gemma":[0.00007284683,0.00008611572,0.0000412598,0.00007128859,0.00007743945,0.000004841821,0.0003089683,0.0002383953,0.000008798363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003643677,"about_ca_system_score_gemma":0.0000642591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002936155,"about_ca_topic_score_gemma":0.0006268015,"domain_scores_codex":[0.9993778,0.00006056474,0.0001308855,0.0002169818,0.00009089924,0.0001228951],"domain_scores_gemma":[0.9987206,0.00003663504,0.00005565801,0.0010052,0.0001313046,0.0000506425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005950606,0.0001254323,0.2263465,0.00002326885,0.00008762067,1.07814e-7,0.0002271456,0.0003040514,0.7663857,0.001328922,0.001397128,0.003714606],"study_design_scores_gemma":[0.0007318615,0.00016112,0.635964,0.00001285542,0.00001893928,0.000002208858,0.0002593611,0.0006758127,0.04486886,0.0003613505,0.3166393,0.0003042995],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793487,0.01699413,0.0001476421,0.0008999989,0.0001973987,0.0002182017,0.00007543751,0.00001177963,0.002106733],"genre_scores_gemma":[0.9962944,0.001194362,0.001380393,0.0002201958,0.0000571353,0.00003204986,0.0005117692,0.000009933468,0.0002998115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7215168,"threshold_uncertainty_score":0.3511697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01634424993803664,"score_gpt":0.3213452924583495,"score_spread":0.3050010425203129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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