{"id":"W2898590125","doi":"10.1093/annonc/mdy287.080","title":"A randomized phase II study of cisplatin plus radiotherapy versus durvalumab plus radiotherapy followed by adjuvant durvalumab versus durvalumab plus radiotherapy followed by adjuvant tremelimumab and durvalumab in intermediate risk, HPV-positive, locoregionally advanced oropharyngeal squamous cell cancer (LA-OSCC) (Canadian Cancer Trials Group HN.9)","year":2018,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre; Ottawa Hospital; London Health Sciences Centre; Jewish General Hospital; Ottawa Regional Cancer Foundation","funders":"","keywords":"Medicine; Durvalumab; Oncology; Tremelimumab; Internal medicine; Radiation therapy; Cancer; Immunotherapy; Nivolumab; Ipilimumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003010452,0.00260159,0.003874784,0.0004758568,0.0005916677,0.001499556,0.002030652,0.002341833,0.01092096],"category_scores_gemma":[0.002625631,0.001061864,0.001970908,0.0006062057,0.001820957,0.001534543,0.0005486003,0.004632237,0.002090374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00167327,"about_ca_system_score_gemma":0.002986044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003260278,"about_ca_topic_score_gemma":0.008387863,"domain_scores_codex":[0.9990494,0.0005011216,0.00004893705,0.0001784207,0.00006007729,0.0001621383],"domain_scores_gemma":[0.9980966,0.0004844457,0.000387561,0.0001609035,0.0001241002,0.0007463697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9834641,0.008140057,0.0001590022,0.0002760258,0.0003189038,0.00001711914,0.00003316803,0.0002113725,0.001294674,0.00008233204,0.000593244,0.005410122],"study_design_scores_gemma":[0.9422383,0.05607008,0.0004874175,0.00001733303,0.0001991753,0.00001412429,0.00001619626,0.000270481,0.0001725628,0.0001191036,0.0003854335,0.000009874669],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.968308,0.003691476,0.001306731,0.001321766,0.001820973,0.01658399,0.002727063,0.0002596962,0.003980373],"genre_scores_gemma":[0.9587237,0.003483466,0.003823535,0.002345359,0.000902575,0.01844831,0.002461483,0.00007519354,0.009736444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01092096,"threshold_uncertainty_score":0.03653431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06117280264449251,"score_gpt":0.4078237154637091,"score_spread":0.3466509128192166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}