{"id":"W2898595037","doi":"10.1093/annonc/mdy272.322","title":"Clinical outcomes in patients (pts) with estrogen receptor–positive (ER+)/human epidermal growth factor receptor 2–negative (HER2–) advanced breast cancer (ABC) with objective response (OR) or without objective response (non-OR) in PALOMA-2","year":2018,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; BC Cancer Agency","funders":"","keywords":"Medicine; Internal medicine; Letrozole; Breast cancer; Palbociclib; Estrogen receptor; Cancer; Phases of clinical research; Metastatic breast cancer; Progression-free survival; Gastroenterology; Oncology; Clinical trial; Gynecology; Overall survival; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001535448,0.0008700296,0.002699147,0.0007343795,0.0001880497,0.00001633539,0.0004045045,0.0005477442,0.0008593179],"category_scores_gemma":[0.002178545,0.0005442334,0.0002140072,0.001316042,0.002378756,0.0006879403,0.0001701629,0.001066696,0.0000337509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001493769,"about_ca_system_score_gemma":0.003906384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00154259,"about_ca_topic_score_gemma":0.00967302,"domain_scores_codex":[0.9921865,0.002933056,0.001555799,0.001412104,0.0007077113,0.001204805],"domain_scores_gemma":[0.99091,0.004339755,0.001334221,0.0006871201,0.002272421,0.0004564794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.4771884,0.001761722,0.4910884,0.00003217315,0.0006961751,0.0001354989,0.007520295,0.000007659732,0.00088376,0.00000621136,0.00006927109,0.02061039],"study_design_scores_gemma":[0.03109937,0.0697063,0.8835174,0.0009995493,0.000101369,0.0000953331,0.004119912,0.000005055027,0.009161479,0.00005443833,0.0004892226,0.0006505455],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992731,0.00005151852,0.00006924578,0.002847663,0.0002743414,0.002856746,0.0008111211,0.00007992479,0.0002784189],"genre_scores_gemma":[0.9909365,0.0001082394,0.005049879,0.001942522,0.0002322004,0.0006406248,0.00003518858,0.0001651772,0.0008897211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4460891,"threshold_uncertainty_score":0.9997009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04555222766477911,"score_gpt":0.4145697970891816,"score_spread":0.3690175694244025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}