{"id":"W2898595037","doi":"10.1093/annonc/mdy272.322","title":"Clinical outcomes in patients (pts) with estrogen receptor–positive (ER+)/human epidermal growth factor receptor 2–negative (HER2–) advanced breast cancer (ABC) with objective response (OR) or without objective response (non-OR) in PALOMA-2","year":2018,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; BC Cancer Agency","funders":"","keywords":"Medicine; Internal medicine; Letrozole; Breast cancer; Palbociclib; Estrogen receptor; Cancer; Phases of clinical research; Metastatic breast cancer; Progression-free survival; Gastroenterology; Oncology; Clinical trial; Gynecology; Overall survival; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000595476,0.0002366432,0.0006471194,0.0001471642,0.0001839103,0.0003390788,0.0002115303,0.0003683285,0.001730988],"category_scores_gemma":[0.0007730529,0.000127531,0.0005649242,0.0002672582,0.000271035,0.0003042488,0.0002185404,0.0006385241,0.0002413342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004017599,"about_ca_system_score_gemma":0.0003392395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00036358,"about_ca_topic_score_gemma":0.0006846521,"domain_scores_codex":[0.9998087,0.00008185374,0.0000162141,0.00003749282,0.00002505946,0.00003075763],"domain_scores_gemma":[0.9996114,0.00009240353,0.0001423945,0.00001559936,0.00002084964,0.0001172813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.4002805,0.005660796,0.4595735,0.0009997503,0.001918731,0.001063419,0.0002816748,0.003014603,0.0112869,0.0002948419,0.003864221,0.1117612],"study_design_scores_gemma":[0.08010381,0.2165675,0.6847394,0.0001315894,0.002385644,0.002661807,0.0003267598,0.00332674,0.003127984,0.0008796059,0.005708953,0.0000403186],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980419,0.0008943193,0.00007209097,0.00009507445,0.00001234327,0.00007864423,0.0002680733,0.000004776439,0.000532751],"genre_scores_gemma":[0.9985595,0.0003655432,0.00008393514,0.0001298501,0.00002849881,0.00009528337,0.0005148645,0.000001170355,0.0002214623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001730988,"threshold_uncertainty_score":0.00579071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04555222766477911,"score_gpt":0.4145697970891816,"score_spread":0.3690175694244025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}