{"id":"W2898608732","doi":"10.1093/annonc/mdy273.395","title":"Phase II open-label, global study evaluating dabrafenib in combination with trametinib in pediatric patients with BRAF V600–mutant high-grade glioma (HGG) or low-grade glioma (LGG)","year":2018,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Trametinib; Dabrafenib; Medicine; MEK inhibitor; Oncology; Internal medicine; Cohort; Glioma; Melanoma; Phases of clinical research; Clinical trial; Cancer research; Cancer; MAPK/ERK pathway; Metastatic melanoma; Kinase; Vemurafenib; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001729234,0.002875351,0.002650705,0.0005192425,0.0003965173,0.001174625,0.001305714,0.001494775,0.004254967],"category_scores_gemma":[0.0009112105,0.0007970192,0.001862107,0.0008491101,0.001334998,0.001264265,0.0005296592,0.004512157,0.001188852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001817271,"about_ca_system_score_gemma":0.003464834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00252383,"about_ca_topic_score_gemma":0.007866299,"domain_scores_codex":[0.9994123,0.0002829301,0.00002369365,0.0001115358,0.00005349702,0.0001160842],"domain_scores_gemma":[0.9990901,0.00008263021,0.0002399466,0.00005587,0.00007737571,0.0004540413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7718599,0.07049445,0.01920341,0.001841551,0.004101945,0.0005596818,0.0004464531,0.004365527,0.03064471,0.0003732942,0.0106863,0.08542268],"study_design_scores_gemma":[0.6611565,0.3107743,0.01945906,0.00005923561,0.0007474349,0.0006841905,0.0001302103,0.00106477,0.001947127,0.0001879917,0.003753016,0.00003609247],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864699,0.002901599,0.0007454122,0.0007382295,0.0001135996,0.003506424,0.003485198,0.0002152602,0.001824266],"genre_scores_gemma":[0.9759067,0.003819814,0.00311445,0.001734692,0.0001885245,0.00530186,0.008025073,0.00008503391,0.001823793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004254967,"threshold_uncertainty_score":0.0142343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0996918227720206,"score_gpt":0.436226634191225,"score_spread":0.3365348114192044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}