{"id":"W2898623497","doi":"10.1016/j.cjca.2018.10.014","title":"Change in Proteinuria or Albuminuria as a Surrogate for Cardiovascular and Other Major Clinical Outcomes: A Systematic Review and Meta-analysis","year":2018,"lang":"en","type":"review","venue":"Canadian Journal of Cardiology","topic":"Chronic Kidney Disease and Diabetes","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"National Health and Medical Research Council; Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Health Solutions; University of Calgary","keywords":"Albuminuria; Medicine; Proteinuria; Meta-analysis; Internal medicine; Kidney disease; Confidence interval; Randomized controlled trial; Clinical trial; Surrogate endpoint; Urology; Kidney","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009518048,0.003441764,0.01982329,0.004366837,0.0005836611,0.003077825,0.002448617,0.002725553,0.004911005],"category_scores_gemma":[0.02072306,0.001993055,0.03822161,0.005231323,0.0007979822,0.002251453,0.001924247,0.00273821,0.0004548348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002114735,"about_ca_system_score_gemma":0.003077744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007239978,"about_ca_topic_score_gemma":0.02589417,"domain_scores_codex":[0.9940041,0.002250923,0.001985728,0.0008531353,0.0006337871,0.0002722764],"domain_scores_gemma":[0.9898345,0.007053532,0.001848757,0.0004282969,0.0006724614,0.0001623527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00188417,0.00003564982,0.003303727,0.2896143,0.6950398,0.0001189075,0.00007342896,0.0002536665,0.0001957672,0.00009388169,0.0005667665,0.008819991],"study_design_scores_gemma":[0.0005719956,0.0001113465,0.002158112,0.009274122,0.9865999,0.00006684159,0.00003290763,0.00007333038,0.00004990773,0.0001043896,0.0009360646,0.00002106506],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003798626,0.9949005,0.0003973568,0.0001080088,0.0001467067,0.0001332537,0.000352002,0.00002169323,0.0001417571],"genre_scores_gemma":[0.1703122,0.8233497,0.002765213,0.001531303,0.0002999314,0.000551925,0.0006714138,0.0000458451,0.0004724558],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01982329,"threshold_uncertainty_score":0.05033684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2156002507622336,"score_gpt":0.4229413715373152,"score_spread":0.2073411207750816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}