{"id":"W2898626672","doi":"10.1523/jneurosci.1662-18.2018","title":"The Elegance of Sonic Hedgehog: Emerging Novel Functions for a Classic Morphogen","year":2018,"lang":"en","type":"review","venue":"Journal of Neuroscience","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Montreal General Hospital; Montreal Neurological Institute and Hospital","funders":"National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Cancer Institute; National Institutes of Health; Fondation Brain Canada; W. Garfield Weston Foundation; McGill University; McGill University Health Centre; National Eye Institute; Vanderbilt University; Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. Department of Defense","keywords":"Morphogen; Sonic hedgehog; Neuroscience; Biology; Hedgehog; Morphogenesis; Embryonic stem cell; Hedgehog signaling pathway; Signalling; Function (biology); Signal transduction; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003938727,0.0005017457,0.0006385637,0.001612367,0.0002512325,0.0008440353,0.0005029349,0.0007930358,0.00158643],"category_scores_gemma":[0.0005157944,0.0001778136,0.0002373368,0.001291942,0.0006803631,0.001549531,0.0006129535,0.001594418,0.001203234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004305977,"about_ca_system_score_gemma":0.0007690716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004892822,"about_ca_topic_score_gemma":0.0008923469,"domain_scores_codex":[0.9998916,0.00001433591,0.00001946815,0.00002305431,0.00004060684,0.0000108491],"domain_scores_gemma":[0.9998177,0.00007661438,0.00001999536,0.000007665511,0.00005340772,0.00002467134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007245709,0.00003093941,0.0002621711,0.01160834,0.0000572603,0.0003908347,0.0001288856,0.0002254765,0.007319592,0.01271719,0.0229772,0.9442097],"study_design_scores_gemma":[0.000003885272,0.0000409192,0.0006163251,0.00119365,0.00005057031,0.001499281,0.00007618046,0.00005330908,0.001463661,0.003321589,0.9916666,0.00001395414],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002251283,0.9977221,0.0002368497,0.0005156393,0.000255486,0.000001338617,0.00001169722,0.000008053515,0.001023742],"genre_scores_gemma":[0.0011887,0.9975682,0.0002373157,0.0002601675,0.0002043446,0.000002404582,0.00001941524,0.000001983978,0.0005175181],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001612367,"threshold_uncertainty_score":0.005307138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09447817651828624,"score_gpt":0.3594986951786118,"score_spread":0.2650205186603256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}