{"id":"W2898683666","doi":"10.1038/s41598-018-34348-0","title":"The Antiarrhythmic Drug, Dronedarone, Demonstrates Cytotoxic Effects in Breast Cancer Independent of Thyroid Hormone Receptor Alpha 1 (THRα1) Antagonism","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Toronto; Sunnybrook Health Science Centre; Princess Margaret Cancer Centre; University Health Network","funders":"Terry Fox Research Institute; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Antagonism; Pharmacology; Breast cancer; Drug; Thyroid hormone receptor; Hormone receptor; Internal medicine; Hormone; Medicine; Cytotoxic T cell; Cancer research; Chemistry; Receptor; Endocrinology; Cancer; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001023958,0.0002065837,0.0002374238,0.0001622915,0.0001102106,0.0002511358,0.0001253807,0.0001979177,0.0007515477],"category_scores_gemma":[0.0001809529,0.000082585,0.0001662392,0.0001362357,0.0001066378,0.0001570672,0.00008219884,0.0003360485,0.0002520355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00022241,"about_ca_system_score_gemma":0.0001531261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003998844,"about_ca_topic_score_gemma":0.0009792281,"domain_scores_codex":[0.999908,0.00001604431,0.00001199468,0.0000156432,0.00003195623,0.00001639748],"domain_scores_gemma":[0.9999222,0.00002215408,0.00001766314,0.00001115272,0.00001440604,0.00001247478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007865843,0.00001887198,0.0001823317,0.00002453205,0.000004965249,0.00007004497,0.000009302192,0.00003598836,0.9973998,0.00006384155,0.00002946199,0.00208202],"study_design_scores_gemma":[0.00002915915,0.0004983293,0.003972067,0.000006006884,0.00002290638,0.0007865548,0.000026452,0.0003537372,0.9914986,0.00004126182,0.002761468,0.000003411237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884967,0.006737387,0.001422261,0.0001486351,0.00004829926,0.00001809843,0.0001812035,0.00003750589,0.002909958],"genre_scores_gemma":[0.9939948,0.003299613,0.0007328505,0.00006481902,0.000008285575,0.00001349323,0.0002655928,0.000008227261,0.001612373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007515477,"threshold_uncertainty_score":0.002514184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003239710493453129,"score_gpt":0.2294629306933101,"score_spread":0.226223220199857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}