{"id":"W2898688174","doi":"10.1038/s42003-018-0196-2","title":"An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2","year":2018,"lang":"en","type":"article","venue":"Communications Biology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Western Economic Diversification Canada; Wellcome Trust; Novartis Pharma; Ontario Genomics Institute; National Cancer Institute; National Research Council Canada; European Federation of Pharmaceutical Industries and Associations; Purdue University Center for Cancer Research; Merck KGaA; National Institutes of Health; Ontario Ministry of Research, Innovation and Science; Ontario Genomics; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Purdue University; Pfizer; University of Saskatchewan; Natural Sciences and Engineering Research Council of Canada; Canadian Light Source","keywords":"Terminal (telecommunication); Glycine; Asparagine; Chemistry; Methyltransferase; Biochemistry; Cell biology; Biology; Computer science; Enzyme; Gene; Amino acid; Computer network; Methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001117537,0.0001643274,0.0001979036,0.00005092308,0.000109612,0.0002328071,0.0001814695,0.0001905919,0.0006349343],"category_scores_gemma":[0.0001829591,0.0001020256,0.0001288042,0.00007780809,0.000182702,0.0001103962,0.0001046314,0.0002179802,0.0003381712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002607967,"about_ca_system_score_gemma":0.000180874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007433862,"about_ca_topic_score_gemma":0.001021338,"domain_scores_codex":[0.9999045,0.00001717931,0.000008647753,0.00002887661,0.00002669031,0.00001397096],"domain_scores_gemma":[0.9999216,0.00001596122,0.00002275882,0.000006994299,0.00001057324,0.0000220573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001067052,0.000007661798,0.0006939181,0.00001373015,0.000003880618,0.00009487771,0.00001467903,0.0001619354,0.9980951,0.00009655645,0.00002423923,0.0006866888],"study_design_scores_gemma":[0.00001778955,0.00006179966,0.005272606,0.000002474451,0.000009098524,0.0006194222,0.0000198789,0.002252012,0.9901447,0.00007794863,0.001516207,0.000005967333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975699,0.0003125009,0.001320929,0.00003783178,0.000007155598,0.000005685924,0.00007849984,0.00002064511,0.0006469595],"genre_scores_gemma":[0.9984439,0.0001061528,0.0008242053,0.00001738163,0.000002024688,0.000003511359,0.0001472194,0.00001095724,0.0004447117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007433862,"threshold_uncertainty_score":0.002124071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03296079950713944,"score_gpt":0.3510296162518928,"score_spread":0.3180688167447533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}