{"id":"W2898778999","doi":"10.1371/journal.pone.0206324","title":"Characterization of immunogenicity of avian influenza antigens encapsulated in PLGA nanoparticles following mucosal and subcutaneous delivery in chickens","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; Wilfrid Laurier University","funders":"Ontario Veterinary College, University of Guelph; Agriculture and Agri-Food Canada; University of Guelph; Ministry of Agriculture, Food and Rural Affairs; Canada First Research Excellence Fund; Ontario Ministry of Agriculture, Food and Rural Affairs; Canadian Poultry Research Council","keywords":"Immunogenicity; Adjuvant; PLGA; Nasal administration; Antigen; Antibody; Immune system; CpG Oligodeoxynucleotide; Vaccination; Chemistry; Hemagglutination assay; Microbiology; Virology; Immunology; Biology; In vitro; Titer; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003123611,0.0001229079,0.0004877337,0.0002881249,0.00004504908,0.000005961193,0.00006961312,0.0000857042,0.00002168532],"category_scores_gemma":[0.0004227486,0.0001196711,0.00004251963,0.0004372837,0.0002256324,0.0001172113,0.0001105226,0.0001535522,0.000006231191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005924401,"about_ca_system_score_gemma":0.00007525594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004848854,"about_ca_topic_score_gemma":0.0002776584,"domain_scores_codex":[0.9985184,0.00007907577,0.0005144729,0.0001979626,0.0003677252,0.0003223528],"domain_scores_gemma":[0.9993452,0.0000650353,0.0001146362,0.0002033858,0.0002158331,0.00005587564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005518349,0.0004961246,0.3880758,0.0001325917,0.000138961,0.00003520674,0.001663201,2.861667e-7,0.6087439,0.000005124008,1.289281e-7,0.0001568268],"study_design_scores_gemma":[0.001097878,0.0003523597,0.4896401,0.0004336304,0.0000468449,0.000002820513,0.00006927879,0.0002522033,0.5080331,0.00001115649,0.000001293299,0.00005930812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989457,0.0004180549,7.368848e-7,0.0000465332,0.00001457093,0.0004696911,0.00002243048,0.00001860357,0.00006368481],"genre_scores_gemma":[0.9993726,0.000254003,0.0002242261,0.00007939994,0.00002378603,0.00000961425,0.00001012536,0.00001612049,0.0000101029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1015644,"threshold_uncertainty_score":0.4880045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07199411327411025,"score_gpt":0.3028760300365362,"score_spread":0.230881916762426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}