{"id":"W2898812156","doi":"10.1016/j.jcmgh.2018.10.012","title":"Proteolytic Processing of the Epithelial Adherens Junction Molecule E-Cadherin by Neutrophil Elastase Generates Short Peptides With Novel Wound-Healing Bioactivity","year":2018,"lang":"en","type":"letter","venue":"Cellular and Molecular Gastroenterology and Hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Crohn's and Colitis Canada; University of Calgary","keywords":"Adherens junction; Wound healing; Proteases; Neutrophil elastase; Inflammatory bowel disease; Medicine; Elastase; Immunology; Context (archaeology); Ulcerative colitis; Proinflammatory cytokine; Cadherin; Inflammation; Disease; Biology; Pathology; Cell; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001451712,0.0003529286,0.0002481369,0.0003002658,0.0001027665,0.0003664683,0.0001318795,0.0003196278,0.0008981053],"category_scores_gemma":[0.0002872315,0.0001186508,0.0003022406,0.0003181233,0.0001345938,0.0005392031,0.0002687692,0.0004721225,0.000344504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000942217,"about_ca_system_score_gemma":0.0001005648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001373567,"about_ca_topic_score_gemma":0.0002431383,"domain_scores_codex":[0.9999006,0.00001579895,0.00001111701,0.00001967546,0.0000317322,0.00002119153],"domain_scores_gemma":[0.9998789,0.00002885327,0.00004860719,0.000008691185,0.00001831252,0.00001659534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001028227,0.00003256958,0.0005408418,0.0002627473,0.00001307325,0.0004217006,0.00003920949,0.00007167955,0.9859645,0.000103427,0.00009787096,0.01234954],"study_design_scores_gemma":[0.00001744729,0.0009874488,0.01179557,0.00004072712,0.00005452542,0.003747897,0.00006112873,0.0004986796,0.9729279,0.0001855361,0.009666489,0.00001678773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9406812,0.03981378,0.01445064,0.0005029276,0.0001548033,0.0001093344,0.0007027113,0.00005944569,0.003525329],"genre_scores_gemma":[0.9685867,0.01553705,0.01122079,0.0003824114,0.00007897009,0.00005941734,0.001011745,0.00002031557,0.003102517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008981053,"threshold_uncertainty_score":0.003004432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006879970811078934,"score_gpt":0.2011531764574189,"score_spread":0.19427320564634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}