{"id":"W2898812156","doi":"10.1016/j.jcmgh.2018.10.012","title":"Proteolytic Processing of the Epithelial Adherens Junction Molecule E-Cadherin by Neutrophil Elastase Generates Short Peptides With Novel Wound-Healing Bioactivity","year":2018,"lang":"en","type":"letter","venue":"Cellular and Molecular Gastroenterology and Hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Crohn's and Colitis Canada; University of Calgary","keywords":"Adherens junction; Wound healing; Proteases; Neutrophil elastase; Inflammatory bowel disease; Medicine; Elastase; Immunology; Context (archaeology); Ulcerative colitis; Proinflammatory cytokine; Cadherin; Inflammation; Disease; Biology; Pathology; Cell; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001862381,0.0005760916,0.0005552443,0.00009442065,0.0002506189,0.00003841926,0.0002758738,0.0009494181,0.000007396508],"category_scores_gemma":[0.00002774625,0.0004573747,0.0001619971,0.00006505194,0.001444026,0.00001182686,0.000283653,0.0007560278,9.862679e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002243566,"about_ca_system_score_gemma":0.0001754627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004019306,"about_ca_topic_score_gemma":0.00009510256,"domain_scores_codex":[0.9973778,0.0003844338,0.0004287358,0.0009575011,0.0001939339,0.0006576306],"domain_scores_gemma":[0.9988136,0.000009866146,0.0003266852,0.000548174,0.0001793199,0.0001223229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001358448,0.000116275,0.02321787,0.0004582688,0.0003502283,0.000329456,0.00003864998,0.00001271489,0.9649132,0.000007643567,0.009090278,0.0001069612],"study_design_scores_gemma":[0.005176879,0.004571154,0.006033912,0.000297201,0.001673357,0.002099264,0.00007475404,0.0011463,0.9355452,0.00008491467,0.04181795,0.001479114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812914,0.0006474123,0.01095238,0.005946801,0.0001877036,0.0007288851,0.0002019156,0.00001796721,0.00002553495],"genre_scores_gemma":[0.9691425,0.00007687703,0.0004419047,0.02898065,0.0004521076,0.0001332814,0.0005608061,0.0001009625,0.0001109312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03272767,"threshold_uncertainty_score":0.9997878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006879970811078934,"score_gpt":0.2011531764574189,"score_spread":0.19427320564634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}