{"id":"W2898841798","doi":"10.3390/cells7110192","title":"Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine Derivatives","year":2018,"lang":"en","type":"article","venue":"Cells","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Narodowe Centrum Nauki","keywords":"Colchicine; Tubulin; Docking (animal); Cytotoxicity; Chemistry; In vitro; Microtubule; Cell culture; Pharmacology; Stereochemistry; Biochemistry; Cancer research; Biology; Cell biology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003774115,0.0005866588,0.0005269987,0.0002047114,0.0001916914,0.0003292579,0.0004086005,0.000281854,0.002171086],"category_scores_gemma":[0.000107072,0.0001504688,0.000300596,0.0002878445,0.0001363644,0.0001569469,0.0001663787,0.0003082981,0.0003140356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004455519,"about_ca_system_score_gemma":0.000275037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003714232,"about_ca_topic_score_gemma":0.004430542,"domain_scores_codex":[0.9999608,0.000006228749,0.000002024085,0.000007929891,0.00001266253,0.0000103748],"domain_scores_gemma":[0.9999731,0.000005261284,0.000006963285,0.000001500838,0.000005214235,0.000008044096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00148089,0.0004863466,0.001983493,0.0009470371,0.0002052114,0.001292072,0.0000912323,0.3644232,0.6030221,0.002871858,0.00203254,0.02116398],"study_design_scores_gemma":[0.0004194826,0.002457054,0.002783305,0.00004849854,0.0002009499,0.0003469738,0.0001615439,0.6183898,0.3630795,0.0005892687,0.01143027,0.00009335758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826453,0.002461265,0.005520591,0.0001822539,0.00007549867,0.0000594597,0.0006797071,0.0002271531,0.008148725],"genre_scores_gemma":[0.9887687,0.001735448,0.006841199,0.00004181043,0.000006432085,0.00004839371,0.0006816402,0.00003964789,0.001836689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003714232,"threshold_uncertainty_score":0.007385254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03923786755759114,"score_gpt":0.2791984003710917,"score_spread":0.2399605328135006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}