{"id":"W2898841798","doi":"10.3390/cells7110192","title":"Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine Derivatives","year":2018,"lang":"en","type":"article","venue":"Cells","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Narodowe Centrum Nauki","keywords":"Colchicine; Tubulin; Docking (animal); Cytotoxicity; Chemistry; In vitro; Microtubule; Cell culture; Pharmacology; Stereochemistry; Biochemistry; Cancer research; Biology; Cell biology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009595743,0.0001263926,0.0002445506,0.00001753535,0.00006679204,0.00001571909,0.00008894707,0.0001005089,0.0001402575],"category_scores_gemma":[0.00003997066,0.00009104502,0.00004207578,0.00006846053,0.0002831237,0.00005733902,0.00008425568,0.00009276204,0.00000215973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000110043,"about_ca_system_score_gemma":0.00001323039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004109845,"about_ca_topic_score_gemma":0.000004079193,"domain_scores_codex":[0.9993706,0.00001669378,0.0001183745,0.0002490927,0.00009402513,0.000151249],"domain_scores_gemma":[0.9994706,0.0001402389,0.000113982,0.0001568632,0.00007031702,0.00004799353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002090249,0.000205688,0.001090912,0.0000396875,0.00003360821,0.000001389653,0.000118223,0.000002847779,0.9959927,0.000283709,0.000007949169,0.002014327],"study_design_scores_gemma":[0.0007038656,0.00006575771,0.002591524,0.00003863481,0.0000128883,0.000001687059,0.00004208629,0.0005700483,0.9956257,0.0000747915,0.0001556944,0.0001173598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830962,0.00003633564,0.001083838,0.00006966723,0.00002692363,0.00006434794,0.00001656026,0.00002243892,0.01558364],"genre_scores_gemma":[0.9994396,0.00001198609,0.0003534023,0.00004209641,0.00008184247,0.000004747765,0.000001439461,0.000007179361,0.00005769604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01634336,"threshold_uncertainty_score":0.3712708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03923786755759114,"score_gpt":0.2791984003710917,"score_spread":0.2399605328135006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}