{"id":"W2898861270","doi":"10.15252/emmm.201809172","title":"A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation","year":2018,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":274,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Université Laval; Centre hospitalier de l'Université Laval","funders":"Instituto de Salud Carlos III; European Society for Medical Oncology; Canadian HIV Trials Network, Canadian Institutes of Health Research; National Cancer Institute; Agència de Gestió d'Ajuts Universitaris i de Recerca; Cancer Research UK; Generalitat de Catalunya; Fundación Científica Asociación Española Contra el Cáncer; Fundación Cellex; AstraZeneca","keywords":"Mutation; Molecular biology; Poly ADP ribose polymerase; Chemistry; Biology; Cancer research; Genetics; DNA; Gene; Polymerase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002251623,0.0003704343,0.000721881,0.0006025662,0.0001015133,0.00001793136,0.0002215962,0.0001619915,0.00126823],"category_scores_gemma":[0.002741704,0.0003222958,0.0001106637,0.001124268,0.0005681052,0.0001141961,0.00006916266,0.0004125874,0.000151925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004512797,"about_ca_system_score_gemma":0.0004073115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002604567,"about_ca_topic_score_gemma":0.00007125743,"domain_scores_codex":[0.9964339,0.0005908522,0.000813163,0.0006593206,0.0009249345,0.0005778025],"domain_scores_gemma":[0.9977669,0.0003630413,0.0002389077,0.0009179636,0.0003530651,0.0003601848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006706002,0.0002965723,0.004022782,0.0001196946,0.0001094712,0.002132752,0.002580879,0.00001188912,0.9640422,0.0008287139,0.0164746,0.002674412],"study_design_scores_gemma":[0.04771562,0.008284053,0.0985722,0.00390817,0.000348875,0.002645701,0.001593721,0.0008964303,0.7491599,0.007651176,0.07802071,0.001203387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9607602,0.001934219,0.005492844,0.02440556,0.0007421053,0.00107328,0.00002412179,0.0001770474,0.005390581],"genre_scores_gemma":[0.9828116,0.0000431834,0.003215182,0.01173124,0.001257402,0.0001207052,0.0001270151,0.00008718445,0.0006064496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2148823,"threshold_uncertainty_score":0.9999229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02386045222621364,"score_gpt":0.3273131591371021,"score_spread":0.3034527069108885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}